摘要
目的探讨重复经颅磁刺激对帕金森病伴快速眼动睡眠行为障碍患者实施治疗的可行性与安全性。方法回顾性分析福州市第二医院2021年3月—2023年3月收治的帕金森病伴快速眼动睡眠行为障碍患者病例资料,查阅并筛选出100例帕金森病伴快速眼动睡眠行为障碍患者完整病例,根据治疗方案分为2组,各50例。参照组采取药物治疗,研究组则在参照组治疗基础上配合重复经颅磁刺激治疗。比较2组治疗效果。结果2组患者治疗后的总睡眠时间(total sleep time,TST)、睡眠效率(sleep efficiency,SE)、快速眼动睡眠时间(rapid eye movement sleep,REMS)比治疗前更高,且研究组治疗后的指标[(360.45±25.68)min、(76.15±5.15)%、(12.85±4.32)min]均高于参照组[(317.85±23.12)min、(68.76±4.31)%、(8.05±1.65)min];而睡眠潜伏期(sleeplatency,SL)、醒觉指数(arousalindex,AI)则要低于治疗前,且研究组治疗后的指标[(17.12±3.45)min、(24.05±2.48)次/h]低于参照组[(24.18±4.36)min、(35.36±3.12)次/h],差异有统计学意义(P<0.05)。治疗后,2组的爱泼沃斯嗜睡量表(Epworth sleeping scale,ESS)评分要低于治疗前,且研究组治疗后评分[(6.01±2.02)分]低于参照组[(8.12±2.05)分],而蒙特利尔认知评估量表(Montreal cognitive assess-ment scale,MoCA)评分、PD睡眠量表(PDsleepscale,PDSS)评分高于治疗前,且研究组治疗后的分数[(25.38±2.76)分、(119.85±11.05)分]明显高出参照组[(22.38±2.13)分、(113.15±10.35)分],差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对于帕金森病伴快速眼动睡眠行为障碍采取重复经颅磁刺激治疗,可取得良好治疗效果,对于患者的睡眠障碍改善、认知功能改善有积极作用,且不会增加患者的不良反应发生率,具有较高的安全性。
Objective To explore the feasibility and safety of repeated repetitive transcranial magnetic stimulation in patients with Parkinson's disease with rapid eye movement sleep behavior disorder.Methods A retrospective analysis was conducted on the case data of Parkinson's disease patients with rapid eye movement sleep behavior disorder admitted to Fuzhou Second Hospital from March 2021 to March 2023.A total of 100 complete cases of Parkinson's disease patients with rapid eye movement sleep behavior disorder were reviewed and screened.According to the treatment plan,they were divided into two groups,with 50 cases in each group.The reference group received medication treatment,while the research group received repeated transcranial magnetic stimulation therapy on the basis of the reference group's treatment.The treatment effects between the two groups were compared.Results The total sleep time(TST),sleep efficiency(SE)and rapideyemovementsleep(REMS)of two groups of patients after treatment were higher than before,and the indicators of the study group after treatment[(360.45±25.68)min,(76.15±5.15)%,(12.85±4.32)min]were higher than those of the reference group[(317.85±23.12)min,(68.76±4.31)%,(8.05±1.65)min].However,sleeplatency(SL),arousalindex(AI)were lower than before treatment,and the indicators of the study group after treatment[(17.12±3.45)min,(24.05±2.48)time/h]were lower than those of the control group[(24.18±4.36)min,(35.36±3.12)time/h],with statistical significance(P<0.05).After treatment,the Epworth sleeping scale(ESS)scores of the two groups were lower than before treatment,and the post-treatment scores of the study group[(6.01±2.02)points]were lower than those of the reference group[(8.12±2.05)points],while the Montreal cognitive assess-ment scale(MoCA)score and PD sleep scale(PDSS)score were higher than before treatment,and the post-treatment scores of the study group[(25.38±2.76)points,(119.85±11.05)points]were significantly higher than those of the reference group[(22.38±2.13)points,(113.15±10.35)points],with statistical significance(P<0.05).The incidence of adverse reactions between two groups was not statistically significant(P>0.05).Conclusion The treatment of repetitive transcranial magnetic stimulation for Parkinson's disease patients with rapid eye movement sleep behavior disorder can obtain significant efficacy,which can effectively improve the patients'Sleep disorder,sleep quality and cognitive function,and will not increase the probability of adverse reactions in patients with high safety.
作者
林仁河
陈仲
陈欢林
蒋小玲
LIN Renhe;CHEN Zhong;CHEN Huanlin;JIANG Xiaoling(Department of Neurology,Fuzhou Second Hospital,Fuzhou Fujian 350007,China)
出处
《中国卫生标准管理》
2024年第5期111-114,共4页
China Health Standard Management
基金
福州市“十四五”临床专科培强培优培育建设项目(20220105)。
关键词
帕金森病
快速眼动睡眠行为障碍
重复经颅磁刺激
睡眠质量
认知功能
不良反应
Parkinson's disease
rapid eye movement sleep behavior disorder
repetitive transcranial magnetic stimulation
sleep quality
cognitive function
adverse reactions
