摘要
目的探讨高迁移率族蛋白B1(high mobility group box 1,HMGB1)、可溶性髓系细胞触发受体-1(soluble myeloid cells trigger receptor-1,sTREM-1)、降钙素原(procalcitonin,PCT)对重症肺炎合并呼吸衰竭患者的预后预测价值。方法选取2020年4月—2023年4月延边大学附属医院收治的78例重症肺炎合并呼吸衰竭患者根据治疗情况将其分为治疗无效组(n=44)与治疗有效组(n=34)。观察2组患者的一般资料、PCT、sTREM-1、HMGB1水平,绘制PCT、sTREM-1、HMGB1及其联合的ROC曲线;分析3项血清指标及其联合与疾病预后的关系。结果治疗无效组呼吸频率、平均动脉压、急性生理与慢性健康状况评分、序贯器官衰竭评分、CRP水平与治疗有效组相应值相比,差异均有统计学意义(P<0.05);治疗无效组PCT、sTREM-1、HMGB1均高于治疗有效组,差异有统计学意义(P<0.05);3种指标联合的AUC值为0.958,95%CI0.920~0.995,敏感度为97.70%,特异度为71.50%,截断值为0.008。结论PCT、sTREM-1、HMGB1三者联合检验对重症肺炎合并呼吸衰竭患者的预后预测价值,其敏感度与特异度较高。
Objective To explore high mobility group box 1(HMGB1),prognosticative value of receptor-1(sTREM-1)and procalcitonin(PCT)in patients with severe pneumonia complicated with respiratory failure.Methods A total of 78 patients with severe pneumonia combined with respiratory failure admitted to Yanbian University Hospital from April 2020 to April 2023 were divided into treatment ineffective group(n=44)and treatment effective group(n=34)according to their treatment conditions.General data,PCT,sTREM-1 and HMGB1 levels of the two groups of patients were observed,and ROC curves of PCT,sTREM-1,HMGB1 and their combination were plotted.The relationship between the three serum indexes and their combination and the prognosis of the disease was analyzed.Results The respiratory rate,mean arterial pressure,acute physiological and chronic health scores,sequential organ failure scores and CRP levels in the ineffective group were compared with those in the effective group,and the differences were significant(P<0.05).The PCT,sTREM-1 and HMGB1 in the ineffective treatment group were higher than those in the effective treatment group,and the differences were significant(P<0.05).The combined AUC value of the three indexes was 0.958,95%CI 0.920-0.995,sensitivity was 97.70%,specificity was 71.50%,and cut-off value was 0.008.Conclusion The combined test of PCT,sTREM-1 and HMGB1 can predict the prognosis of patients with severe pneumonia complicated with respiratory failure,and its sensitivity and specificity are high.
作者
石蓉
金爱花
SHI Rong;JIN Aihua(Department of Clinical Laboratory,Yanbian University Hospital/Yanbian Hospital,Yanji Jilin 133000,China)
出处
《中国卫生标准管理》
2024年第5期115-118,共4页
China Health Standard Management
