摘要
目的:分析高分辨率磁共振(HRMRI)参数检测联合血清MMP9、hs-CRP指标对大脑中动脉粥样硬化性狭窄病人急性卒中发生的预测价值。方法:选取183例大脑中动脉粥样硬化性狭窄病人,根据住院期间是否发生急性卒中将其分为急性卒中组89例和无急性卒中组94例。分析狭窄程度及血清MMP9、hs-CRP水平预测大脑中动脉粥样硬化性狭窄病人急性卒中的价值。结果:急性卒中组易损斑块、狭窄程度、Essen卒中风险评分(ESRS)、血清MMP9、hs-CRP水平均高于无急性卒中组(P<0.05);狭窄程度及血清MMP9、hs-CRP水平预测大脑中动脉粥样硬化性狭窄病人发生急性卒中的AUC分别为0.886、0.857、0.634;三者联合预测的AUC为0.923。结论:血清MMP9、hs-CRP联合HRMRI参数检测可提高了评估急性卒中预测的准确性。
Objective:To detect the expression levels of serum matrix metalloproteinase-9(MMP9)and high-sensitivity C reactive protein(hs-CRP)in patients with middle cerebral artery atherosclerotic stenosis and analyze the value of MMP9 and hs-CRP combined with high-resolution magnetic resonance imaging(HRMRI)parameters in predicting the occurrence of acute stroke.Methods:A total of 183 patients with middle cerebral artery atherosclerotic stenosis were selected and divided into the acute stroke group(89 cases)and non-acute stroke group(94 cases)according to whether acute stroke occurred during hospitalization.Predictive values of stenosis degree,serum MMP9 and hs-CRP levels in patients with middle cerebral artery atherosclerotic stenosis were analyzed.Results:Vulnerable plaque,degree of stenosis,Essen stroke risk score(ESRS)and levels of MMP9,hs-CRP in the acute stroke group were higher than those in non-acute stroke group(P<0.05).The area under curve(AUC)of degree of stenosis and the levels of MMP9 and hs-CRP in the predictive of acute stroke in patients with atherosclerotic stenosis were 0.886,0.857 and 0.634,respectively,and AUC of their combination was 0.923.Conclusions:Serum MMP9 and hs-CRP combined with HRMRI parameters can greatly improve the accuracy of prediction in acute stroke.
作者
郎悦
余浩佳
陈星弛
王赛男
张慧
LANG Yue;YU Haojia;CHEN Xingchi;WANG Sainan;ZHANG Hui(Department of Neuroscience,The Second Hospital of Dalian Medical University,Dalian Liaoning 116023,China)
出处
《蚌埠医学院学报》
CAS
2024年第2期195-199,共5页
Journal of Bengbu Medical College
基金
辽宁省临床能力建设项目青年基金项目(LNCC-D22-2015)。
关键词
大脑中动脉粥样硬化性狭窄
急性卒中
高分辨率磁共振
超敏C反应蛋白
基质金属蛋白酶9
middle cerebral artery atherosclerotic stenosis
acute stroke
high-resolution magnetic resonance imaging
high-sensitivity C reactive protein
matrix metalloproteinase 9
