摘要
目的:深入探究左甲状腺素钠片在改善早期先兆流产合并亚临床甲减患者的甲状腺功能指标上的效果,并进一步分析其对妊娠结局的潜在影响。方法:选取在2020年5月—2023年2月聊城市妇幼保健院收治的552例早期先兆流产合并亚临床甲减患者作为研究样本,通过随机数字表法将患者分为对照组(n=276)和观察组(n=276)。对照组予以甲状腺片治疗,观察组予以左甲状腺素钠片治疗。比较两组治疗前及治疗1个月后甲状腺功能[游离甲状腺素(FT_(4))、甲状腺过氧化物酶抗体(TPOAb)及促甲状腺激素(TSH)]、激素水平[β-人绒毛膜促性腺激素(β-hCG)、雌二醇(E_(2))、孕酮(P)]及妊娠结局[流产、早产、产后出血、胎膜早破、胎儿宫内窘迫、低体重儿、胎儿畸形、剖宫产、自然分娩]。结果:治疗前,两组甲状腺功能及激素水平比较,差异均无统计学无意义(P>0.05)。治疗1个月后,两组FT_(4)水平比较,差异无统计学意义(P>0.05);TPOAb及TSH水平均相较对照组有所降低,β-hCG、E_(2)、P水平相较对照组均有所提升,差异均有统计学意义(P<0.05)。观察组流产、早产、产后出血、胎膜早破、胎儿宫内窘迫、低体重儿、胎儿畸形不良妊娠结局相对于对照组均明显偏低;剖宫产相对于对照组明显偏低,自然分娩更高,差异均有统计学意义(P<0.05)。结论:对早期先兆流产合并亚临床甲减患者给予左甲状腺素钠片治疗,能够有效改善其甲状腺功能及激素水平,降低不良妊娠结局的出现,提升自然分娩率。
Objective:To thoroughly investigate the effectiveness of Levothyroxine Sodium Tablets in improving thyroid function indicators in patients with early threatened miscarriage and subclinical hypothyroidism,and to further analyze its potential impact on pregnancy outcomes.Method:A total of 552 patients with early threatened miscarriage and subclinical hypothyroidism admitted to Liaocheng Women and Children's Health Care Hospital from May 2020 to February 2023 were selected as research subjects,these patients were divided into a control group(n=276)and an observation group(n=276)by random number table method.The control group received treatment with Thyroid Tablets,while the observation group was treated with Levothyroxine Sodium Tablets.The thyroid function[free thyroxine(FT_(4)),thyroid peroxidase antibody(TPOAb),and thyroid-stimulating hormone(TSH)]and hormone levels[β-human chorionic gonadotropin(β-hCG),estradiol(E_(2)),progesterone(P)]as well as pregnancy outcomes[miscarriage,preterm birth,postpartum hemorrhage,premature rupture of membranes,intrauterine fetal distress,low birth weight,fetal malformation,cesarean section,natural childbirth]in both groups were compared before treatment and one month after treatment.Result:Before treatment,there were no statistically significant differences in thyroid function and hormone levels between the two groups(P>0.05).One month after treatment,there was no significant difference in FT_(4) level between the two groups(P>0.05);levels of TPOAb and TSH in the observation group were lower than those in the control group,while levels ofβ-hCG,E_(2),and P were higher,the differences were statistically significant(P<0.05).The observation group had significantly lower adverse pregnancy outcomes including miscarriage,premature birth,postpartum hemorrhage,premature rupture of membranes,intrauterine fetal distress,low birth weight infants,and fetal malformations compared to the control group;the pregnancy outcome of cesarean section was significantly lower compared to the control group,the natural childbirth rate was higher,the differences were statistically significant(P<0.05).Conclusion:Treatment with Levothyroxine Sodium Tablets in patients with early threatened miscarriage and subclinical hypothyroidism can effectively improve thyroid function and hormone levels,reduce the incidence of adverse pregnancy outcomes,and increase the rate of natural childbirth.
作者
邢慧慧
卢飞飞
李倩
XING Huihui;LU Feifei;LI Qian(Laboratory Department,Liaocheng Women and Children's Health Care Hospital,Liaocheng 252000,China;不详)
出处
《中国医学创新》
CAS
2024年第6期37-41,共5页
Medical Innovation of China
关键词
左甲状腺素钠片
早期先兆流产
亚临床甲减
甲状腺功能
妊娠结局
Levothyroxine Sodium Tablets
Early threatened miscarriage
Subclinical hypothyroidism
Thyroid function
Pregnancy outcomes
