摘要
目的 研究胰高血糖素样肽-1受体(GLP-1R)基因遗传变异与血压钠钾反应性的关系。方法 2004年在陕西眉县共招募了来自124个家系的514名受试者,并建立了“盐敏感性高血压研究队列”。对受试者进行了为期3 d的正常饮食、7 d的低盐饮食、7 d的高盐饮食和7 d的高盐补钾饮食干预,并测量不同干预期的血压,并采集外周血标本。此外,采用MassARRAY检测平台对GLP-1R基因的8个单核苷酸多态性(SNP)进行了分型检测。结果 GLP-1R基因SNP rs9462472与低盐期的收缩压、舒张压和平均动脉压反应呈显著相关性。而SNP rs2268637则与高盐期的收缩压反应呈显著相关性。此外,SNP rs2268637还与高盐补钾饮食期的收缩压和平均动脉压反应呈显著相关性。结论 GLP-1R基因的多态性与血压钠钾反应性密切相关,提示其参与调节血压盐敏感性及钾反应性的发生与发展。
Objective To investigate the association between genetic variations in the glucagon-like peptide-1 receptor(GLP-1R) gene and BP responses to sodium and potassium intake.Methods A total of 514 subjects from 124 families were recruited in Meixian County,Shaanxi Province,in 2004,resulting in the establishment of a “salt-sensitive hypertension study cohort”.The subjects followed a dietary regimen which involved a normal diet for 3 days,a low-salt diet for 7 days,a high-salt diet for 7 days,and a high-salt potassium-supplemented diet for 7 days.BP measurement was conducted at different intervention periods,and peripheral blood samples were collected.Additionally,eight single nucleotide polymorphisms(SNPs) of the GLP-1R gene were genotyped using the MassARRAY detection platform.Results The GLP-1R gene SNP rs9462472 exhibited a significant association with systolic BP,diastolic BP,and mean arterial pressure response to high-salt intervention.Similarly,SNP rs2268637 showed a significant association with systolic BP response to high-salt intervention.Furthermore,SNP rs2268637 was significantly associated with systolic BP and mean arterial pressure responses to high-salt plus potassium supplementation intervention.Conclusion Our findings indicate a significant association of genetic variations in the GLP-1R gene with BP responses to sodium and potassium intake.This suggests that the GLP-1R gene plays a role in the regulation of BP salt sensitivity and potassium sensitivity.
作者
常鸣珂
褚超
杜鸣飞
贾昊
孙月
胡桂霖
张玺
王丹
罗文婧
严瑜
满子悦
汪洋
牟建军
CHANG Mingke;CHU Chao;DU Mingfei;JIA Hao;SUN Yue;HU Guilin;ZHANG Xi;WANG Dan;LUO Wenjing;YAN Yu;MAN Ziyue;WANG Yang;MU Jianjun(Department of Cardiovascular Medicine,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
2024年第2期212-218,共7页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金资助项目(No.81870319,No.82070437)
陕西省自然科学基金项目(No.2021JM-257,No.2021JM-588)
西安交通大学第一附属医院院基金(No.2019QN-06、No.2021ZXY-14)
西安交通大学第一附属医院临床研究项目(No.XJTU1AF-CRF-2022-002、No.XJTU1AF2021CRF-021)。
关键词
GLP-1R
基因多态性
盐敏感性
盐
钾
高血压
glucagon-like peptide-1 receptor(GLP-1R)
gene polymorphism
salt sensitivity
salt
potassium
hypertension
