摘要
1例73岁老年女性重症骨质疏松者行髋关节置换术后,采用地舒单抗抗骨质疏松,6 d后主诉下肢有抽搐感,复查血钙2.0 mmol/L。临床药师结合患者症状和用药史,判断与地舒单抗注射液不良反应有关,及时调整医嘱,加用葡萄糖酸钙颗粒和骨化三醇胶丸促进钙的吸收,纠正低钙血症。临床药师积极参与治疗方案的制定,提供全程化的药学服务,保证重症高危骨质疏松患者的治疗效果,保障患者用药安全,提高患者的预后和生活质量。
A 73 year old female patient with severe osteoporosis underwent hip arthroplasty and was then treated with denosumab for osteoporosis.After 6 days,the patient complained of convulsions in the lower limbs and her blood calcium content was 2.0 mmol/L after follow-up examination.The clinical pharmacists judged that this adverse reaction was associated with denosumab injection by considering her symptoms and medication history,and promptly adjusted the medical prescription,added calcium gluconate granules and osteotriol gel pills to promote calcium absorption,and her hypocalcaemia was finally corrected.Clinical pharmacists actively participate in the development of treatment plans and provide comprehensive pharmacy services to promote the therapeutic efficacy of patients with severe high-risk osteoporosis,ensure the safety of their medication,and improve their prognosis and quality of life.
作者
林燕
刘晓琰
LIN Yan;LIU Xiaoyan(Department of Pharmacy,Huangpu Branch,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)
出处
《上海医药》
CAS
2024年第5期70-72,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
骨质疏松
地舒单抗
药学监护
临床药师
osteoporosis
denosumab
pharmacological monitoring
clinical pharmacist
