摘要
转录因子EB(TFEB)是小眼畸形相关转录因子家族成员,通过调节自噬-溶酶体相关基因的表达在脂质代谢等多种生物过程中发挥重要作用。TFEB的活性与细胞定位可通过蛋白质的翻译后修饰进行调节。本文就TFEB翻译后修饰对自噬的调节作用进行综述,旨在加深对动脉粥样硬化等自噬异常所致疾病发病机制的理解,为相应疾病的防治提供新的思路和干预靶点。
Transcription factor EB(TFEB)is a member of the microphthalmia associated transcription factor family.It plays an important role in lipid metabolism and other biological processes by regulating the expression of autophagy and lysosomal related genes.The activity and cellular localization of TFEB can be regulated by posttranslational modifications of proteins.This paper discusses the mechanism of autophagy regulation by TFEB posttranslational modification,aiming to help understand the pathogenesis of related diseases caused by abnormal autophagy,and provides new ideas and feasible intervention targets for the prevention and treatment of corresponding diseases.
作者
杨一茗
柴嘉音
王雯
YANG Yiming;CHAI Jiayin;WANG Wen(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases,Beijing 100069,China)
出处
《中国动脉硬化杂志》
CAS
2024年第3期185-193,共9页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(91839107)
北京市自然科学基金项目(7242005)。
关键词
转录因子EB
自噬
蛋白质翻译后修饰
transcription factor EB
autophagy
posttranslational modifications
