摘要
动脉粥样硬化是心脑血管疾病发生、发展的主要病理基础。动脉粥样硬化形成中存在巨噬细胞胞葬缺陷。有缺陷的胞葬导致未清除的凋亡细胞堆积,继发性坏死,从而导致动脉粥样硬化特征性的坏死核心形成和斑块不稳定。完整的胞葬过程包括识别(“找我”)阶段、吞噬(“吃我”)阶段和后处理反应(吞噬后)阶段。已有报道miRNA在动脉粥样硬化胞葬中参与调节关键信号传导和脂质稳态。文章讨论了动脉粥样硬化过程中胞葬的重要作用及胞葬缺陷对动脉粥样硬化的影响,尤其针对胞葬吞噬阶段“吃我”和“不吃我”信号在动脉粥样硬化全程炎症参与下胞葬缺陷的调节影响、miRNA在动脉粥样硬化中调节脂质代谢及炎症消退、动脉粥样硬化过程中miRNA靶向巨噬细胞的胞葬的微调节作用等方面的研究文献进行综述。
Atherosclerosis is the main pathological basis for the occurrence and development of cardiovascular and cerebrovascular diseases.Macrophage efferocytosis deficiency exists in the formation of atherosclerosis.Defective efferocytosis leads to the accumulation of uncleared apoptotic cells and secondary necrosis,leading to characteristic formation of necrotic core and plaque instability in atherosclerosis.The complete process of efferocytosis includes recognition(“find me”)stage,phagocytosis(“eat me”)stage,and the post-processing reaction(digestion)stage.It has been reported that miRNA is involved in the regulation of key signal transduction and lipid homeostasis in atherosclerotic efferocytosis.This paper discussed the important role of efferocytosis in the process of atherosclerosis and the influence of efferocytosis defect on atherosclerosis.This review focuses on the regulatory effects of“eat me”and“don t eat me”signals of efferocytosis in the overall inflammation of atherosclerosis,and meanwhile the regulation of miRNA on lipid metabolism and inflammation regression in atherosclerosis,and the fine tuning of miRNA targeting macrophage efferocytosis in the process of atherosclerosis.
作者
程坤
顾宁
CHENG Kun;GU Ning(Nanjing University of Chinese Medicine,Nanjing,Jingsu 210046,China;Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jingsu 210022,China)
出处
《中国动脉硬化杂志》
CAS
2024年第3期249-256,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金面上项目(81173399)
南京市医学科技发展重点项目(ZKX21060)
南京市中医药科技专项项目(ZYYB202213)。
