摘要
心力衰竭是心血管疾病终末期的致命阶段,因其死亡率和再住院率一直居高不下,故给社会带来了巨大的医疗负担。肠道微生态(IM)是人体最大、最复杂的微生态系统,它是由数以万计的微生物寄居在人体的胃肠道内,这些微生物被统称为肠道菌群(GM)。近些年来随着对肠道菌群研究的不断深入,越来越多的研究发现肠道菌群的失衡会改变心力衰竭患者体内基础代谢,促进全身炎症级联反应,是心力衰竭发生发展的关键诱因之一,因此以肠道微生物稳态作为治疗心力衰竭的新切入点将是医学研究的热点。然而中医理论“脾为之卫”涵盖了脾主运化、脾主升清、藏意主思等生理功能,肠道菌群与“脾为之卫”的职能有一定的相似性。文章从整体观念出发,以中医“脾为之卫”理论为切入,就肠道微生态失衡与心力衰竭发病机制进行阐述,为心力衰竭中医治疗或药物研究提供参考。
Heart failure is a fatal stage of end-stage cardiovascular disease,which brings a huge medical burden to the society because of its high mortality and re-hospitalisation rates.Intestinal microecology is the largest and most complex microecosystem of human body.It is inhabited by tens of thousands of microorganisms in human gastrointestinal tract.In recent years,with the deepening of the study of intestinal flora,more and more studies have found that the imbalance of intestinal microecology can cause changes of metabolites in heart failure patients,which is one of the key triggers for the development of heart failure,therefore,using the intestinal microbial homeostasis as a new entry point for the treatment of heart failure will be a hotspot in medical research.However,the theory of Chinese medicine,“the spleen is the guardian”,covers the physiological functions of the spleen,such as the spleen s main function of transporting,spleen s main function of ascending and clearing,and its main function of hiding camping,etc.,and the functions of intestinal flora and the“spleen is the guardian”are similar to a certain extent.Therefore,this paper starts from a holistic viewpoint and takes the theory of“spleen as the guardian”in Chinese medicine as an entry point to elaborate on the pathogenesis of intestinal microecological imbalance and heart failure,so as to provide a reference for Chinese medicine treatment or drug research.
作者
刘长兴
郭心怡
王博宇
时娜
陈秋涵
周亚滨
王贺
LIU Changxing;GUO Xinyi;WANG Boyu;SHI Na;CHEN Qiuhan;ZHOU Yabin;WANG He(Helongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610032,China;The Second Department of Cardiovascular Medicine,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China)
出处
《中国动脉硬化杂志》
CAS
2024年第3期263-270,共8页
Chinese Journal of Arteriosclerosis
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发[2022]75号)。
关键词
脾为之卫
肠道微生态
心力衰竭
spleen as the guardian
intestinal microecology
heart failure
