摘要
目的:评价血清隐球菌荚膜多糖抗原(CrAg)检测在疑似肺隐球菌病(PC)患者中的诊断价值,并分析影响其结果的因素。方法:以病理检查为金标准,选取2020年1月至2022年11月疑似PC的患者,均行血清隐球菌荚膜抗原检测。结果:在234例疑似PC的患者中,最终确诊为PC的患者127例,非PC患者107例。血清CrAg检测诊断肺隐球菌病的灵敏度为65.4%,特异度86.0%,其曲线下面积(AUC)[95%置信区间(95%CI)]为0.756(0.6936,0.8197)。CrAg阴性和阳性患者的年龄、基础疾病史、病灶类型及分布部位差异有统计学意义(P<0.05)。结论:血清CrAg检测有很好的特异度,有助于筛查疑似肺隐球菌病的患者,以便早期诊断及指导治疗。
Objective:To evaluate the diagnostic value of serum cryptococcal capsular polysaccharide antigen(CrAg)in patients with suspected pulmonary cryptococcosis(PC)and analyze the factors influencing the results.Methods:With pathological examination as the gold standard,the patients who were suspected of PC from January 2020 to November 2022 were selected.All patients were tested for serum CrAg.Results:Among the 234 patients suspected of PC,127 patients were finally diagnosed with PC and 107 patients were not.The sensitivity and specificity of serum CrAg in the diagnosis of PC were 65.4%and 86.0%,and its area under the curve(AUC)value(95%confidence interval)was 0.756(0.6936,0.8197).Significant differences were found in age,basic diseases,and types and distribution of focal infections between the positive CrAg group and the negative CrAg group(P<0.05).Conclusion:The detection of serum CrAg has a good specificity,which helps screen patients suspected of pulmonary cryptococcosis for early diagnosis and treatment guidance.
作者
荣玉琼
潘珍珍
朱苗娟
杨炯
RONG Yuqiong;PAN Zhenzhen;ZHU Miaojuan;YANG Jiong(Dept.of Respiratory and Critical Care Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2024年第2期229-234,共6页
Medical Journal of Wuhan University
基金
湖北省自然科学基金(编号:220171519)。
关键词
肺隐球菌病
隐球菌荚膜多糖抗原
灵敏度
特异度
受试者特异曲线
Pulmonary Cryptococcosis
Cryptococcus Capsular Polysaccharide Antigen
Sensitivity
Specificity
Subject Specific Curve
