摘要
目的 研究外周血过氧化物酶6(PRDX6)与稳定期慢性阻塞性肺疾病(COPD)患者临床特征及频繁急性加重的关系。方法 选择2021年1月至2022年12月期间寿县人民医院呼吸内科收治的80例稳定期COPD患者作为研究对象。根据既往12个月内急性加重情况分为频繁急性加重组(n=42)和非频繁急性加重组(n=38)。比较两组患者外周血PRDX6水平及临床指标的差异,采用logistic回归模型分析稳定期COPD患者频繁急性加重的影响因素。结果 频繁急性加重组的外周血PRDX6水平、第一秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、FEV1占预计值百分比(FEV1/pred)低于非频繁急性加重组,差异有统计学意义(t=14.509、4.302、5.755、4.907,P<0.05),BODE指数、COPD评估测试(CAT)评分均高于非频繁急性加重组,差异有统计学意义(t=4.391、9.212,P<0.05);稳定期COPD患者外周血PRDX6水平与FEV1、FEV1/FVC、FEV1/pred呈正相关(r=0.341、0.327、0.401、0.294、0.301、0.342),与BODE评分、CAT评分呈负相关(r=-0.328、-0.394、-0.275、-0.351 P<0.05);logistic回归分析显示:外周血PRDX6水平增加是频繁急性加重的保护因素,CAT评分增加是频繁急性加重的危险因素。结论 稳定期COPD患者外周血PRDX6水平降低与肺功能减退、临床症状加重以及频繁急性加重相关。
Objective To investigate the relationship between peripheral blood peroxiredoxin 6(PRDX6)and clinical characteristics,frequent acute exacerbation in patients with stable chronic obstructive pulmonary disease(COPD).Methods 80 stable COPD patients admitted to our department from January 2021 to December 2022 were selected as the study subjects.They were divided into two groups based on the frequency of acute exacerbation within the past 12 months:the frequent acute exacerbation group(n=42)and the non-frequent acute exacerbation group(n=38).The differences of peripheral blood PRDX6 level and clini-cal indicators between the two groups of patients were compared,and the logistic regression model was used to analyze the factors influencing frequent acute exacerbation in stable COPD patients.Results The peripheral blood PRDX6 levels,the first second forced expiratory volume(FEV1),FEV1/forced vital capacity(FVC),and FEV1 to predicted percentage(FEV1/pred)of the frequent acute exacerbation group were lower than those in the non-frequent acute exacerbation group(t=14.509,4.302,5.755,4.907,P<0.05).Additionally,the BODE index and COPD assessment test(CAT)score were higher in the frequent acute exacerbation group compared to the non-frequent acute exacerbation group(t=4.391,9.212,P<0.05).The peripheral blood PRDX6 level in stable COPD patients showed a positive correlation with FEV1,FEV1/FVC,FEV1/pred(r=0.341,0.327,0.401,0.294,0.301,0.342),and a negative correlation with the BODE index and CAT score(r=-0.328,-0.394,-0.275,-0.351,P<0.05).Logistic regression analysis revealed that an increased periph-eral blood PRDX6 level was a protective factor for frequent acute exacerbation,while an increased CAT score was a risk factor for frequent acute exacerbation.Conclusion The decreased peripheral blood levels of PRDX6 in stable COPD patients are associated with decreased lung function,worsening clinical symptoms,and frequent acute exacerbations.
作者
孙江
高骏飞
杨培草
SUN Jiang;GAO Junfei;YANG Peicao(Respiratory Department of Shouxian People's Hospital,Huainan,Anhui,China,232200)
出处
《分子诊断与治疗杂志》
2024年第3期407-411,共5页
Journal of Molecular Diagnostics and Therapy
基金
安徽省卫生健康委科研项目(AFWJ20223926)。
关键词
慢性阻塞性肺疾病
频繁急性加重
过氧化物酶6
影响因素
Chronic obstructive pulmonary disease
Frequent acute exacerbation
Peroxiredoxin 6
Influence factor
