摘要
目的 探讨miR-141-3p、白细胞介素-18(IL-18)与老年脑出血患者病情严重程度及预后的相关性。方法 分析2021年1月至2022年12月于青岛市城阳区人民医院接受治疗的老年脑出血患者116例临床资料,根据病情严重程度将其分为轻度组(n=51)、中度组(n=38)和重度组(n=27);随访6个月,依据预后情况分为预后良好组(n=79)与预后不良组(n=37)。并选取同期体检健康志愿者30名作为对照组。比较对照组与轻、中、重度组的miR-141-3p、IL-18水平,分析患者miR-141-3p、IL-18水平与疾病严重程度相关性。对患者因素单、多因素分析,并绘制ROC曲线分析患者miR-141-3p、IL-18水平对其预后的预测价值。结果 miR-141-3p水平比较:对照组>轻度组>中度组>重度组,IL-18水平比较:重度组>中度组>轻度组>对照组(F=116.151、77.832,P均<0.05);Spearman分析法分析结果显示,患者疾病严重程度与miR-141-3p呈显著的负相关(r=-0.668,P<0.05),与IL-18水平呈显著的正相关(r=0.583,P<0.05);预后不良组与预后良好组比较,年龄、是否合并高血压、糖尿病、冠心病、疾病严重程度、是否破入脑室、出血量及miR-141-3p、IL-18水平差异具有统计学意义(t/χ^(2)=2.106、5.945、5.988、4.353、19.669、6.707、4.130、7.659、7.405,P<0.05);多因素分析结果显示,合并高血压、疾病越严重、miR-141-3p水平降低、IL-18水平升高为老年脑出血患者预后不良独立危险因素(P<0.05);ROC曲线结果显示,miR-141-3p、IL-18及两项联合评估的AUC分别为0.900、0.825及0.960(P<0.05)。结论 miR-141-3p、IL-18与老年脑出血患者病情严重程度及预后密切相关,且miR-141-3p、IL-18与联合检测对老年脑出血患者预后具有良好的评估效能。
Objective To investigate the correlation between miR-141-3p and interleukin-18(IL-18)and the severity and prognosis of senile patients with cerebral hemorrhage.Methods Clinical data from 116 elderly patients with cerebral hemorrhage treated at Chengyang District People's Hospital in Qingdao City from January 2021 to December 2022 were analyzed.The patients were divided into three groups based on disease severity:mild group(n=51),moderate group(n=38)and severe group(n=27).They were followed up for 6 months and categorized into either a good prognosis group(n=79)or a poor prognosis group(n=37).Thirty healthy volunteers were selected as a control group.The levels of miR-141-3p and IL-18 were compared between the control group and the mild,moderate and severe groups.The correlation between the levels of miR-141-3p and IL-18 and the severity of the disease was analyzed.The prognostic value of miR-141-3p and IL-18 levels in patients was assessed through single and multi-factor analysis.Furthermore,an ROC curve was generated to evaluate the prognostic value of the patients.Results Comparison of miR-141-3p levels:control group>mild group>moderate group>severe group;comparison of IL-18 levels:severe group>moderate group>mild group>control group(F=116.151,77.832,P<0.05).Spearman analysis showed that disease severi-ty was significantly negatively correlated with miR-141-3p(r=-0.668,P<0.05),and positively correlated with IL-18(r=0.583,P<0.05).Compared with the poor prognosis group and the good prognosis group,there were significant differences in age,whether patients were combined with hypertension,diabetes,coronary heart dis-ease,severity of disease,whether patients had ventricular rupture,blood loss,and miR-141-3p and IL-18 levels(t/χ^(2)=2.106,5.945,5.988,4.353,19.669,6.707,4.130,7.659,7.405,P<0.05).The results of multi-factor analysis showed that hypertension,more severe disease,decreased miR-141-3p level and increased IL-18 level were independent risk factors for poor prognosis in elderly patients with cerebral hemorrhage(P<0.05).The ROC curve results showed that the AUC of miR-141-3p,IL-18 and the two combined evaluations were 0.900,0.825 and 0.960,respectively(P<0.05).Conclusion MiR-141-3p and IL-18 are closely related to the severity and prognosis of elderly patients with cerebral hemorrhage.The combined detection of miR-141-3p and IL-18 shows good efficacy in evaluating the prognosis of elderly patients with cerebral hemorrhage.
作者
袁蕾
万克苗
孙宁涛
YUAN Lei;WANG Kemiao;SUN Ningtao(Department of Neurology,Qingdao Chengyang District People's Hospital,Qingdao,Shandong,China,266109;Department of Cardiology,Qingdao Chengyang District People's Hospital,Qingdao,Shandong,China,266109;Department of Gerontology,Qingdao Chengyang District People's Hospital,Qingdao,Shandong,China,266109)
出处
《分子诊断与治疗杂志》
2024年第3期476-480,共5页
Journal of Molecular Diagnostics and Therapy
基金
山东省医药卫生科技发展计划项目(2016WS0290)。
