摘要
硫酸多糖具有抗凝血、抗病毒、抗菌、抗癌及促进创伤愈合等多种生物活性,且能抑制生物体内存在的各种酶的过度活性,有效维持生命健康和防止衰老。本文对褐藻糖胶(Fucoidan,FPS)、紫菜多糖(Porphyran,PP)、硫酸软骨素(Chondroitin Sulfate,CS)等3种硫酸多糖抑制透明质酸酶(Hyaluronidase,HAase)、胶原蛋白酶(Collagenase,CLS)、酪氨酸酶(Tyrosinase,TYR)和弹性蛋白酶(Elastase,PPE)的活性作用进行了研究。结果表明,FPS对HAase、CLS、PPE均有抑制作用;PP和CS对HAase、PPE有较强抑制作用,其中CS具有极强的HAase抑制活性;硫酸多糖抑制HAase活性作用可能与硫酸基有关,需进一步验证;多糖分子量越小,其抑制HAase活性作用越大。本研究有望为硫酸多糖在保湿护肤、抗黑色素生成、维持肌肤弹性等方面的开发利用提供参考。
Sulfated polysaccharides exhibit a range of biological activities,including anticoagulation,antivirus,antibacterial,anticancer,and promotion of wound healing,as well as inhibiting the excessive activity of various enzymes within living organisms,effectively maintaining life health and preventing aging.This paper investigates the inhibition of three sulfated polysaccharides-fucoidan(FPS),porphyran(PP),and chondroitin sulfate(CS)on the activity of hyaluronidase HAase,collagenase(CLS),tyrosinase(TYR),and elastase(PPE).The results indicate that FPS exhibits inhibitions on HAase,CLS,and PPE;PP and CS have strong inhibitions on HAase and PPE,with CS showing particularly strong inhibitory activity against HAase.The activities of sulfated polysaccharides on HAase may be linked with sulfates,which requires further verification;it has been observed that the smaller the molecular weight of the polysaccharides,the greater their inhibition on HAase activity.This research is expected to provide a reference for the development and utilization of sulfated polysaccharides in aspects such as moisturizing skincare,anti-melanin production,and maintaining skin elasticity.
作者
张洋
ZHANG Yang(Wuhu Institute of Technology,Wuhu 241003,China)
出处
《食品安全导刊》
2024年第4期74-78,共5页
China Food Safety Magazine
基金
安徽省高校自然科学研究重点项目“海洋绿藻中提取成分的相关活性研究”(KJ2020A0921)。
关键词
硫酸多糖
褐藻糖胶
紫菜多糖
硫酸软骨素
酶
抑制作用
sulfated polysaccharides
fucoidan
porphyrin
chondroitin sulfate
enzyme
inhibition
