摘要
铁过载和中医“血瘀证”在再生障碍性贫血(简称再障)的发生发展中发挥着重要作用。围绕再障“瘀证”的发生机制和临床特征,结合中医“取象比类”和相关临床基础研究进展,系统阐述了铁过载与再障中医“瘀证”潜在的相关性。铁螯合治疗契合“祛瘀生新”的中医理论,有利于改善造血,而从中医“补肾活血”着手,同样有助于疾病临床疗效的提升。
Iron overload and “Stasis syndrome” played a crucial role in the development of aplastic anemia(AA).According to the mechanism and characteristic of “Stasis”,using comparative state and clinical research datum,we elaborated the role of iron overload in the formation of “Stasis” syndrome in AA.Iron chelation can promote the hematopoiesis which goes accordance with the theory of “removing stasis and promoting new”in Traditional Chinese Medicine.Based on this,treatment based on “Tonifying kidney and promoting blood circulation” in AA also benefit in improving the clinical efficiency.
作者
吴迪炯
洪耀南
孙泽星
周郁鸿
WU Dijiong;HONG Yaonan;SUN Zexing;ZHOU Yuhong(The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,310006;Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou,310006;The First School of Clinical Medicine Zhejiang Chinese Medical University,Hangzhou,310053)
出处
《浙江中医杂志》
2024年第2期100-102,共3页
Zhejiang Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目“补肾活血方”通过调控自噬介导的p53乙酰化减轻再生障碍性贫血造血干细胞“铁死亡”的机制研究,编号:82174138
浙江省卫生健康科技计划项目重型再生障碍性贫血患者脂质代谢的变化特征及其在联合免疫抑制治疗疗效评估中的价值研究,编号:2022RC216
浙江省中医药科技计划项目NRF2-HO-1通路在“补肾活血方”调控再生障碍性贫血骨髓脂肪细胞再生分化“铁损伤”中的作用研究,编号:2020ZB085。
关键词
再生障碍性贫血
瘀证
铁过载
活血
aplastic anemia
stasis syndrome
iron overload
activating blood
