摘要
目的 探讨美托洛尔联合稳心颗粒对心房颤动(AF)患者导管消融术后房性心动过速(AT)的治疗价值。方法 选取2018年5月至2022年1月在苏北人民医院心血管内科诊断为AF并成功行导管消融术的患者253例,采用掷币法随机分为稳心颗粒组(56例)、美托洛尔组(79例)、联合组(79例)、对照组(39例)。比较4组患者治疗AT次数、最长AT心搏次数、平均心率及不良反应等情况。结果 对照组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均高于基线,差异有统计学意义(P<0.01)。稳心颗粒组、美托洛尔组、联合组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均低于基线,差异有统计学意义(P<0.01);联合组术后1年平均心率、AT阵数、AT最长心搏次数及Ⅰ、Ⅱ、Ⅲ类房性过早搏动次数均低于稳心颗粒组和美托洛尔组,差异有统计学意义(P<0.05);稳心颗粒组、美托洛尔组、联合组不良反应总发生率比较无显著差异(7.1%vs 13.9%vs 8.9%,P=0.301)。结论 美托洛尔联合稳心颗粒可用于治疗AF患者导管消融术后AT,可有效降低平均心率,减少AT发生次数、房性过早搏动次数、减少AT最长心搏次数,可能减少术后AF复发,安全性较高。
Objective To explore the therapeutic value of metoprolol combined with Wenxin Keli(a Chinese patent drug)on atrial tachycardia(AT)after catheter ablation in patients with atrial fibrillation(AF).Methods A total of 290patients who were diagnosed with AF and underwent catheter ablation successfully in the Department of Cardiovascular Medicine of Northern Jiangsu People's Hospital from May 2018to January 2022were enrolled,and were randomly divided into Wenxin Granule group(Group W),metoprolol group(Group M),combined group(Group MW)and blank control group(Group C).The times of AT,heart beats during the longest AT episode,average heart rate and adverse reactions were compared among the 4groups.Results The mean heart rate,episodes of AT,heart beats during the longest AT episode,and numbers of premature atrial contractions(PAC)of classⅠ,ⅡandⅢin Group C in 1year after operation were all sig-nificantly higher than the baseline levels(P<0.01),so were in the Group W,Group M and Group MW(P<0.01).Group MW had obviously lower mean heart rate,episodes of AT,heart beats dur-ing the longest AT episode,and numbers of PAC of classⅠ,ⅡandⅢwhen compared with Group W and Group M(P<0.05).There was no significant difference in the total incidence of ad-verse reactions in Group W,Group M and Group MW(7.1%vs 13.9%vs 8.9%,P=0.301).Con-clusion Metoprolol combined with Wenxin Keli can be used to treat AT after AF catheter abla-tion.The combination can effectively reduce the average heart rate,episodes of AT,numbers of PAC and heart beats during the longest AT episode,and thus decrease the recurrence of postopera-tive AF with high safety.
作者
谷慧阳
顾翔
朱业
Gu Huiyang;Gu Xiang;Zhu Ye(Second Department of Cardiovascular Medicine,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2024年第3期245-249,共5页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家自然科学基金(81800250)
中国博士后科学基金(2022M711417)
扬州市科技计划项目(YZ2023096)。
