摘要
目的探讨甲状腺功能与阿尔茨海默病(AD)脑容量变化的关系。方法选择2020年1月至2022年3月在四川大学华西医院龙泉医院神经内科接受诊治的64例AD患者(AD组)和36例轻度认知功能障碍(MCI)患者(MCI组)。另选择同期19例没有认知障碍或精神疾病史的健康者作为正常对照组。采用电化学发光法检测游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)水平。结果与正常对照组比较,MCI组和AD组患者FT_(3)水平显著降低[2.50(2.28,2.60)ng/L、2.07(1.97,2.30)ng/L vs 2.76(2.55,2.93)ng/L,P<0.05],且AD组显著低于MCI组。AD组患者中脑、脑桥、延髓、左右侧海马体、左右侧杏仁核、左右侧颞叶体积显著低于MCI组(P<0.05,P<0.01)。Spearman相关性分析和多元线性回归分析显示,AD组患者FT_(3)、FT_(4)水平与左右侧海马体和左右侧杏仁核体积呈正相关,TSH水平与左右侧海马体和左右侧杏仁核体积呈负相关(P<0.05,P<0.01);TSH与左侧颞叶体积呈负相关(P<0.05)。结论甲状腺功能失调与脑容量减小有关,可能促进AD患者认知功能障碍和脑萎缩进展。
Objective To investigate the relationship between thyroid function and brain volume in patients with Alzheimer's disease(AD).Methods A total of 64AD patients(AD group)and 36 patients with mild cognitive impairment(MCI group)admitted in our department from January 2020to March 2022were enrolled in this study.Another 19healthy individuals who had no cogni-tive impairment or psychiatric disorders were enrolled and served as normal control group.Their levels of free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and thyroid stimulating hormone(TSH)were detected by electrochemical luminescence assay.Results FT_(3)level was significantly decreased in the MCI group and AD group than the normal control group[2.50(2.28,2.60)ng/L and 2.07(1.97,2.30)ng/L vs 2.76(2.55,2.93)ng/L,P<0.05],and the decrease in the AD group was more obvious than that in the MCI group.The volumes of the midbrain,pons,medulla oblon-gata,hippocampus,amygdala and temporal lobe were significantly smaller in the AD group than the MCI group(P<0.05,P<0.01).Spearman correlation analysis and multivariate linear regres-sion analysis showed that in the AD patients,FT_(3)and FT_(4)levels were positively while TSH level was negatively correlated with the volumes of both right and left hippocampus and amygdala(P<0.05,P<0.01),and TSH level was also negatively correlated with the left temporal lobe volume(P<0.05).Conclusion Thyroid dysfunction is associated with reduced brain volume in AD patietns,and may contribute to the progression of AD cognitive dysfunction and brain atrophy.
作者
杨斐
宁波
祝美蓉
唐维菊
刘君霞
Yang Fei;Ning Bo;Zhu Meirong;Tang Weiju;Liu Junxia(Department of Neurology,Longquan Hospital of Sichuan University West China Hospital,Chengdu 610000,Sichuan Province,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2024年第3期292-296,共5页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
四川省卫生和计划生育委员会科研项目(17PJ098)。
