摘要
肺癌是世界上发病率和死亡率最高的恶性肿瘤之一,明确其病因、发病机制及药物防治方法是目前研究热点。小鼠是肺癌临床前研究中最常用的实验动物,根据不同的研究策略和目的选择合适的小鼠模型。目前常用的小鼠肺癌模型包括诱发性模型、移植物模型及基因工程模型等,根据研究目的选择不同的小鼠模型。回顾国内外肺癌小鼠模型相关文献报道,归纳总结常用肺癌小鼠模型的研究进展,为肺癌研究提供参考。
Lung cancer is one of the malignant tumors with the highest incidence and mortality in the world,and its etiology,pathogenesis and drug prevention and treatment methods are currently research hotspots.Mice are the most commonly used experimental animals in preclinical research on lung cancer,and suitable mouse models are selected according to different research strategies and purposes.At present,commonly used mouse lung cancer models include induced models,graft models and genetically engineered models.This paper reviews the relevant literature reports of lung cancer mouse models at home and abroad,summarizes the research progress of commonly used lung cancer mouse models,and provides a reference for lung cancer research.
作者
于国兴
刘翠兰
张鑫
杜静
YU Guoxing;LIU Cuilan;ZHANG Xin;DU Jing(Department of Hematology,Binzhou Medical University Hospital,Shandong Binzhou 256600,China;Medical Research Center,Binzhou Medical University Hospital,Shandong Binzhou 256600,China)
出处
《现代肿瘤医学》
CAS
2024年第7期1361-1366,共6页
Journal of Modern Oncology
基金
国家自然科学基金项目(编号:31900441)
山东省自然科学基金项目(编号:ZR2019MC026)
山东省中医药发展计划(编号:2019-0514)。
关键词
肺癌
小鼠模型
诱发性模型
移植性模型
基因工程模型
lung cancer
animal models
induced models
xenograft models
genetic engineering model
