摘要
目的探讨利用4D-CTA结合SDF-1a/CXCR4信号通路评估颅内后交通动脉瘤破裂风险的价值。方法将50名未破裂颅内前交通动脉瘤患者和50名破裂颅内前交通动脉瘤患者分为未破裂组1和破裂组1。所有患者均接受4D-CTA检查并检测血清SDF-1a水平。非破裂组1接受了12个月的随访后把后脉瘤破裂的患者被纳入破裂组2,动脉瘤未破裂的患者被纳入非破裂组2。结果诊断颅内后交通动脉瘤破裂的Wn、AR、L、SR、SDF-1a及其组合的AUC值均大于0.70。破裂组2 Wn、AR、L、SR和SDF-1a及其组合预测颅内后交通动脉瘤破裂的AUC值均大于0.70。结论4D-CTA联合SDF-1a能有效区分破裂的颅内后交通动脉瘤并预测破裂风险。
Objective To investigate the value of 4D-CTA combined with SDF-1a/CXCR4 signaling pathway in evaluating the risk of intracranial aneurysm rupture.Methods Fifty patients with unruptured intracranial posterior communicating aneurysms and 50 patients with ruptured intracranial posterior communicating aneurysms were divided into unruptured group 1 and ruptured group 1.All patients underwent 4D-CTA examination and serumSDF-1alevel was detected.Non-ruptured group 1 was followed up for 12 months(After conservative treatment),on this basis,patients with ruptured posterior communicating aneurysms were included in ruptured group 2,and patients with unruptured posterior communicating aneurysms were included in non-ruptured group 2.Results The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in diagnosing ruptured intracranial posterior communicating aneurysms were all greater than 0.70.The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in predicting ruptured intracranial posterior communicating aneurysms in ruptured group 2 were all greater than 0.70.Conclusion 4D-CTA combined with SDF-1acan effectively distinguish ruptured intracranial posterior communicating aneurysms and predict the risk of rupture.
作者
徐艺铭
钟剑锋
李斌
周欣颜
朱红丽
梁靖
廖承德
XU Yiming;ZHONG Jianfeng;LI Bin;ZHOU Xinyan;ZHU Hongli;LIANG Jing;LIAO Chengde(Dept.of Radiology,Yan’an Hospital,Kunming Yunnan 650051,China)
出处
《昆明医科大学学报》
CAS
2024年第3期59-64,共6页
Journal of Kunming Medical University
基金
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202401AY0700-358)
云南省教育厅科学研究基金资助项目(2024J0399)
昆明市心血管影像技术中心(2023-SW(技术)-04)
昆明市“十百千”工程(2021-SW(后背)-09)。
