摘要
目的:采用湿法压片及减压干燥法制备清风消痛片并评价其质量。方法:以膨胀度、溶解性、脆碎度为指标,优化片剂处方工艺;以黄嘌呤氧化酶抑制作用评价清风消痛片的降尿酸作用,采用高效液相色谱法测定片剂中有效成分含量。结果:得最优工艺参数为最佳稀释剂为甘露醇,质量比为1∶2.5,润滑剂为滑石粉与硬脂酸镁联用(质量比1∶6),滑石粉加入量为2%,崩解剂为羧甲基淀粉钠质量比例为1∶0.25;在此条件下所得清风消痛片检查药典符合规定,片中苍术素、盐酸小檗碱、落新妇苷的含量分别为0.038,0.013,0.006 mg/片;清风消痛片水溶液对黄嘌呤氧化酶具有抑制作用,供试品质量浓度为24 mg/mL浓度时,黄嘌呤氧化酶的抑制率达到92.22%。结论:经验证实验结果证明清风消痛片工艺简单,含有多种成分,有明显活性,具有开发前景。
Objective:To prepare Qingfengxiaotong tablets by wet pressing and vacuum drying and evaluate its quality.Methods:The expansion degree,solubility and molding rate were used as indexes to optimize the form μLation process.The effect of Qingfengxiaotong tablet on lowering uric acid was evaluated by xanthine oxidase inhibition.The content of active components in the tablet was determined by HPLC.Results:The optimum process parameters were as follows:the best diluent was mannitol,the ratio was 1∶2.5,the lubricant was talc powder combined with magnesium stearate(1∶6),the addition amount of talc powder was 2%,and the disintegrant was Sodium carboxymethyl starch,the ratio was 1∶0.25.The contents of atractylotin,berberine hydrochloride and astilbin in the obtained Qingfengxiaotong tablet were 0.038,0.013 and 0.006 mg/tablet,respectively.Qingfengxiaotong Tablet aqueous solution has an inhibitory effect on xanthine oxidase.When the concentration of test product is 24 mg/mL,the inhibitory rate of xanthine oxidase reaches 92.22%.Conclusion:The experimental resμLts show that Qingfengxiaotong tablet is simple in process,contains many ingredients,has obvious activity,and has development prospect.
作者
刘艳林
李筱玲
陈珍
梁佳毅
王湘
徐晓婷
闫宁
Liu Yanlin;Li Xiaoling;Chen Zhen;Liang Jiayi;Wang Xiang;Xu Xiaoting;Yan Ning(College of Biology Pharmacy and Food Engineering,Shangluo University,Shangluo 726000,China;Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources,Shangluo 726000,China)
出处
《山东化工》
CAS
2024年第4期185-189,共5页
Shandong Chemical Industry
基金
陕西省大学生创新创业训练计划项目(S202211396069)。
关键词
清风消痛
片剂
减压干燥
黄嘌呤氧化酶抑制作用
refreshing
breeze for relieving pain
tablet
vacuum drying
oxidase inhibition
