摘要
目的探究血清PCT和CRP联合检测对脓毒症患者的诊断价值。方法选取2022年3月—2023年3月本院收治的100例脓毒症患者作为观察组,同时选取100例健康人作为对照组,采用电化学发光分析仪检测血清PCT,采用全自动生化分析仪检测血清CRP,并比较血清PCT、CRP及PCT+CRP在诊断脓毒症中的敏感性与特异性。结果观察组患者的PCT水平为(11.3±9.35)ng/mL,而对照组为(0.02±0.01)ng/mL,两组比较,观察组PCT水平显著升高,差异具有统计学意义(P<0.05);观察组患者的CRP水平为(78.95±16.64)mg/L,而对照组为(3.79±0.35)mg/L,两组比较,观察组CRP水平显著升高,差异具有统计学意义(P<0.05);根据得到的PCT、CRP水平计算出各自试验结果对脓毒症诊断的敏感性和特异性指标,结果显示:PCT、CRP和PCT+CRP联合诊断脓毒症中的敏感性与特异性分别为88%与74%、93%与37%和97%与84%,PCT+CRP联合诊断脓毒症中的敏感性与特异性明显高于PCT、CRP单独诊断,差异非常明显,具有统计学意义(P<0.05)。结论相比较于单独检测,血清PCT和CRP联合检测能提高脓毒症诊断的特异性和敏感性,对脓毒症患者的诊断价值更大,值得推广。
Objective To explore diagnostic value of combined detection of serum procalcitonin(PCT)and C-reactive protein(CRP)for sepsis patients.Methods The paper chose 100 patients with sepsis admitted to our hospital from March 2022 to March 2023 as observation group,and 100 healthy individuals as control group at the same time,detected serum PCT with electrochemiluminescence analyzer,and serum CRP with fully automated biochemical analyzer.Sensitivity and specificity of serum PCT,CRP,and PCT+CRP in diagnosis of sepsis was compared.Results PCT level in observation group was(11.3±9.35)ng/mL,significantly higher than(0.02±0.01)ng/mL in control group,with statistically significant difference(P<0.05).CRP level in observation group was(78.95±16.64)mg/L,significantly higher than(3.79±0.35)mg/L in control group,difference was statistically significant(P<0.05).Based on PCT and CRP levels,sensitivity and specificity indicators for sepsis diagnosis was calculated.Results showed sensitivity and specificity of PCT,CRP,and PCT combined with CRP was 88%and 74%,93%and 37%,and 97%and 84%respectively in diagnosis of sepsis.Sensitivity and specificity of PCT combined with CRP was significantly higher than PCT and CRP only in diagnosis of sepsis,with statistically significant difference(P<0.05).Conclusion Combined detection of serum PCT and CRP can improve specificity and sensitivity of sepsis diagnosis,and has higher diagnostic value than that individual test,which is worth promoting.
作者
罗晓兰
LUO Xiaolan(Pingguo City People's Hospital,Baise,Guangxi 531499)
出处
《智慧健康》
2024年第1期97-100,105,共5页
Smart Healthcare
