摘要
目的:通过分析抗黑素瘤分化相关基因5抗体(MDA5)阳性皮肌炎(DM)患者合并快速进展性间质性肺病(RPILD)和非RPILD的临床特点差异,探讨合并RPILD发生的危险因素。方法:回顾性分析南京医科大学炎性肌病及结缔组织病相关间质性肺病专病联盟组织收集的251例抗MDA5抗体阳性皮肌炎(MDA5+DM)患者临床资料,将其根据有无合并RPILD进行分组,采用t检验、U检验、χ^(2)检验及Logistic回归分析合并RPILD患者的临床特点,探讨RPILD发生的危险因素。结果:将251例患者分为RPILD组(89例)和非RPILD组(162例),2组患者性别、年龄、病程、红细胞沉降率(ESR)、C反应蛋白(CRP)、抗Ro-52抗体阳性、铁蛋白(SF)、抗MDA5抗体滴度比较,差异均有统计学意义(P<0.05)。单因素Logistic回归分析显示年龄、ESR、抗MDA5抗体滴度、性别(男性)、CRP、抗Ro-52抗体均有统计学意义(OR>1,P<0.05);多因素Logistic回归分析显示性别(男性)、CRP、抗Ro-52抗体有统计学意义(OR>1,P<0.05)。结论:年龄、ESR、抗MDA5抗体滴度可能增加MDA5+DM患者发生RPILD的风险,但不是独立危险因素;性别(男性)、CRP升高、抗Ro-52抗体阳性可能是MDA5+DM患者合并RPILD的独立危险因素,均与RPILD的发生呈正相关。
Objective:To compare the clinical characteristics between patients with anti-melanoma differentiation-associated gene 5 antibody(MDA5)-positive dermatomyositis combined with and without rapidly progressive interstitial lung disease(RPILD),and explore the risk factors of this combined disease.Methods:The clinical data were collected from 251 patients with anti-MDA5 antibody-positive dermatomyositis by the Inflammatory Myopathy and Connective Tissue Disease-related Interstitial Lung Disease Specialty Alliance Organization of Nanjing Medical University,retrospectively analyzed,and grouped according to the presence or absence of comorbid RPILD.The clinical characteristics of patients with comorbid RPILD were analyzed by using the t-test,the U-test,the χ^(2)-test,and the Logistic regression to discuss the risk factors for the occurrence of RPILD.Results:The 251 patients were divided into the RPILD group(89 patients)and the non-RPILD group(162 patients).Comparison of gender,age,disease duration,blood sedimentation(ESR),C-reactive protein(CRP),anti-Ro-52 antibody positivity,ferritin(SF),and anti-MDA5 antibody titer in the 2 groups showed statistically significant differences between groups(P<0.05).Logistic univariate analysis showed that the dfferences in age,ESR,anti-MDA5 antibody titer,sex(male),CRP elevation,and anti-Ro-52 antibody positivity were statistically significant(OR>1,P<0.05),and Logistic regression multifactor analysis showed that the dfferences in sex(male),CRP,and anti-Ro-52 antibody positivity were statistically significant(OR>1,P<0.05).Conclusions:Age,ESR,and anti-MDA5 antibody titer may increase the risk of RPILD in patients with MDA5+DM but are not independent risk factors.Male,elevated CRP,and positive anti-Ro-52 antibody may be independent risk factors for the occurrence of RPILD combined withanti-MDA5+DM.
作者
徐艳
于哲
程路
臧银善
XU Yan;YU Zhe;CHENG Lu;ZANG Yinshan(Department of Rheumatology and Immunology,the Affiliated Suqian First People's Hospital of Nanjing Medical University,Suqian 223800,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2024年第4期195-198,共4页
Journal of Clinical Dermatology
关键词
皮肌炎
抗黑素瘤分化相关基因5抗体
间质性肺病
快速进展性
抗Ro-52抗体
dermatomyositis
anti-melanoma differentiation-associated gene 5 antibody
interstitial lung disease,rapidly progressive
anti-Ro-52 antibody
