摘要
目的 分析在诊断原发性肝癌患者时采取联合血清甲胎蛋白(AFP)、糖类抗原125(CA12-5)、癌胚抗原(CEA)肿瘤标志物检测的诊断价值。方法 选取2022年1月—2023年3月在本院医治的60例原发性肝癌患者,检测血清AFP、CA12-5、CEA指标,并且以手术病理检查作为金标准,分析单独检测以及联合检测的诊断结果、诊断效能。结果 分析诊断结果,患者经手术病理检查确诊阳性36例,阴性24例;经AFP检测确诊阳性27例,阴性18例;经CA12-5检测确诊阳性19例,阴性20例;经CEA检测确诊阳性18例,阴性17例;经三项联合检测确诊阳性34例,阴性17例。分析诊断效能,血清AFP、CA12-5、CEA联合检测灵敏度(94.44%)、准确度(85.00%)高于单独检测,漏诊率(5.56%)低于单独检测,差异显著有统计学意义(P<0.05)。联合检测与单独检测的特异度、误诊率差异无统计学意义(P>0.05)。结论 在诊断原发性肝癌患者中,采用联合AFP、CA12-5、CEA肿瘤标志物检测方式,有着较为理想的诊断价值,能够提高灵敏度、准确度,降低漏诊率,故而可以作为诊断有效方法之一,值得推广以及普及。
Objective To analyze the diagnostic value of combined serum alpha-fetoprotein(AFP),cancer antigen 125(CA12-5) and carcinoembryonic antigen(CEA) tumor markers in the diagnosis of primary liver cancer.Methods A total of 60 patients with primary liver cancer treated in our hospital from January 2022 to March 2023 were selected to detect serum AFP,CA12-5 and CEA indexes,and the diagnostic results and diagnostic efficacy of single detection and combined detection were analyzed using surgical pathologic examination as the gold standard.Results The diagnosis results were analyzed,36 cases were positive and 24 cases were negative by surgical pathological examination.AFP detection confirmed 27 positive cases and 18 negative cases;There were 19 positive cases and 20negative cases confirmed by CA12-5 test,18 positive cases and 17 negative cases confirmed by CEA test,34 positive cases and 17 negative cases confirmed by three combined tests.The sensitivity(94.44%)and accuracy(85.00%) of combined detection of AFP,CA12-5 and CEA in serum were higher than that of single detection,and the missed detection rate of AFP,CA12-5 and CEA in serum was(5.56%) lower than that of single detection,the difference was significant(P<0.05).There was no significant difference in specificity and misdiagnosis rate between combined detection and single detection(P> 0.05).Conclusion In the diagnosis of primary liver cancer patients,the combined detection of AFP,CA12-5and CEA tumor markers has ideal diagnostic value,which can improve sensitivity and accuracy,and reduce the rate of missed diagnosis.Therefore,it can be used as one of the effective diagnostic methods,worthy of promotion and popularization.
作者
成昌宏
CHENG Changhong(Department of Clinical Laboratory,Ganyu District People's Hospital,Lianyungang,Jiangsu 222100)
出处
《智慧健康》
2024年第2期8-11,共4页
Smart Healthcare
关键词
肿瘤标志物
联合检测
原发性肝癌
Tumor markers
Combined detection
Primary liver cancer
