摘要
疟疾是由疟原虫感染所致的全球危害最严重的三大传染病之一。疟原虫的裂殖子、动合子和子孢子均具有特征性的内膜复合体(IMC)。IMC定位于质膜下,在胞质侧与膜下网络紧密相连。IMC在细胞分裂过程中提供支撑骨架,维持细胞的形态和稳定性,参与疟原虫发育和入侵宿主细胞等过程。深入研究IMC蛋白的结构、功能和转录调控机制,对研发相应的抑制剂或阻断剂以阻断疟疾传播有重要意义。本文就近年来IMC蛋白结构及其转录调控机制的研究进展进行综述。
Malaria is one of the world’s three most serious infectious diseases which caused by Plasmodium spp.The Plasmodium merozoite,ookinete,and sporozoite all have characteristic endomembrane complexes(IMCs).IMC is localized under the plasma membrane and is closely linked to the subpellicular protein network on the cytoplasmic side of the membrane.IMC is involved in the parasite development and invasion of the host cells by providing a support backbone during cell division,maintaining cell morphology and stability.Indepth studies of the structure,function and transcriptional regulation mechanism of IMC protein are of great significance for the development of corresponding inhibitors or blockers to block malaria transmission.In this paper,we reviewed the research progress of IMC protein structure and transcriptional regulation mechanisms in recent years.
作者
韩竹茜
朱晓彤
HAN Zhuxi;ZHU Xiaotong(Department of Immunology,College of Basic Medical Science,China Medical University,Shenyang 110122,Liaoning,China)
出处
《中国寄生虫学与寄生虫病杂志》
CSCD
北大核心
2024年第1期111-116,120,共7页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(81971961)。
关键词
疟原虫
内膜复合体
肺泡蛋白
棕榈酰化
磷酸化
Plasmodium
Inner membrane complex
Alveolins
Palmitoylation
Phosphorylation
