摘要
目的 探讨2型糖尿病(T2DM)患者血清可溶性肿瘤坏死因子(TNF)样凋亡弱诱导因子(sTWEAK)、可溶性CD40配体(sCD40L)水平与糖尿病微血管并发症(DMA)的相关性。方法 选取2021年3月-2023年3月航天中心医院收治的150例T2DM患者为研究对象,根据患者是否合并DMA分为DMA组(n=69)及T2DM组(n=81)。检测并比较两组患者血清sTWEAK、sCD40L水平及临床资料,采用Logistic回归分析影响T2DM并发微血管病变的危险因素,绘制受试者工作特征曲线(ROC)分析sTWEAK、sCD40L对T2DM并发微血管病变的预测价值。结果 DMA组患者血清sTWEAK、sCD40L水平均高于T2DM组(P<0.05);DMA组的病程、FPG及HbA1c、sTWEAK、sCD40L水平均高于T2DM,差异均有统计学意义(P<0.05);Logistic分析结果显示病程长、HbA1c高水平、sTWEAK高水平及sCD40L高水平均是导致T2DM并发微血管病变的独立危险因素(P<0.05)。ROC结果显示,血清sTWEAK、sCD40L单独及联合预测T2DM并发微血管病变的AUC(95%CI)分别为0.714(0.635~0.785)、0.744(0.666~0.812)、0.859(0.792~0.910),二者联合的预测效能优于单独检测(Z=2.626、2.395,P<0.05)。结论 血清sTWEAK、 sCD40L在DMA患者中均异常升高,与DMA关系密切,sTWEAK、sCD40L联合对于T2DM并发微血管病变的预测价值较高。
Objective To investigate the correlation between serum levels of soluble tumor necrosis factor(TNF)apoptosis weakly inducible factor(sTWEAK),soluble CD40 ligand(sCD40L)and diabetic microvascular complications(DMA)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 150 T2DM patients admitted to the hospital from March 2021 to March 2023 were selected asstudy objects.The patients were divided into DMA group(n=69)and T2DM group(n=81)according to whether they had DMA.The serum levels of sTWEAK,sCD40L and clinical data of the 2 groups were detected and compared.Logistic regression analysis was used to determine the risk factors of T2DM complicated with microangiopathopathy.Receiver operating characteristic curve(ROC)was drawn to analyze the predictive value of sTWEAK and sCD40L in T2DM complicated microangiopathy.Results Serum sTWEAK and sCD40L levels in DMA group were higher than those in T2DM group(P<0.05).The disease duration,FPG,HbA1c,sTWEAK and sCD40L levels in DA group were higher than those in T2DM group,and the differences were statistically significant(P<0.05).Multivariate Logistic analysis showed that long course of disease,high level of HbA1c,high level of sTWEAK and high level of sCD40L were independent risk factors for T2DM complicated microangiopathopathy(P<0.05).ROC results showed that AUC(95%CI)of serum sTWEAK and sCD40L alone and combined in predicting T2DM microangiopathopathy were 0.714(0.635~0.785),0.744(0.666~0.812)and 0.859(0.792~0.910),respectively.The pre-diction efficiency of combined detection was better than that of single detection(Z=2.626,2.395,P<0.05).Conclusion Serum sTWEAK and sCD40L are abnormally elevated in DMA patients,which is closely related to DMA.The combination of sTWEAK and sCD40L has high predictive value for T2DM complicated microangiopathopathy.
作者
尹婧婧
窦立冬
王昱
YIN Jingjing;DOU Lidong;WANG Yu(Department of Geriatric Medicine,Space Center Hospital,Beijing100049,China)
出处
《新疆医科大学学报》
CAS
2024年第3期383-387,共5页
Journal of Xinjiang Medical University
基金
中国航天科工集团课题项目(2019-LCYL-012)。
关键词
2型糖尿病
可溶性肿瘤坏死因子样凋亡弱诱导因子
可溶性CD40配体
糖尿病微血管并发症
Type 2 diabetes(T2DM)
soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK)
soluble CD40 ligand(sCD40L)
diabetic microvascular complications(DMA)
