摘要
环磷酰胺(cyclophosphamide,CTX)在抗癌化疗过程中伴随骨髓抑制、肠黏膜损伤等毒副作用,严重影响患者治疗的耐受性及预后。近年来,多糖因其抗癌、抗炎症及免疫调节等实际应用价值被作为抗肿瘤药物的减毒增效辅剂。本文系统总结多糖精制技术,并从免疫调节、抗氧化以及肠道、肝肾、生殖系统保护多角度阐述其对CTX的减毒机制,论述多糖通过直接或间接杀伤肿瘤与CTX发挥的协同增效作用。从减毒和增效两方面归纳多糖在癌症化疗过程中的调控途径,旨在为多糖的减毒增效相关机制研究提供借鉴,同时为CTX毒副作用的改善途径提供新方向。
Anticancer chemotherapy with cyclophosphamide(CTX)is accompanied by toxic side effects such as bone marrow suppression and intestinal mucosal injury,which seriously affects the treatment tolerance and prognosis of patients.In recent years,polysaccharides have been used as detoxifying and synergistic adjuncts for antitumor drugs due to their anticancer,anti-inflammatory,and immunoregulatory activities.This paper systematically summarizes polysaccharide purification technologies,elaborates on the detoxification mechanism of polysaccharides on CTX from multiple perspectives such as immunomodulation,antioxidation,intestinal protection,liver and kidney protection,and reproductive system protection,and discusses the synergistic effect of polysaccharides with CTX by directly or indirectly killing tumors.Furthermore,the regulatory pathways of polysaccharides in cancer chemotherapy are summarized from two aspects:toxicity reduction and efficacy enhancement.We hope that this review could provide a reference for research on the mechanism of action of polysaccharides in reducing the toxicity and enhancing the efficacy of CTX,and provide new directions for reducing the toxic side effects of CTX.
作者
张彩璇
淑英
李杨
黄磊
郭明珠
ZHANG Caixuan;SHU Ying;LI Yang;HUANG Lei;GUO Mingzhu(College of Food Science and Technology,Hebei Agricultural University,Baoding 071000,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2024年第7期322-331,共10页
Food Science
基金
河北省高等学校科学研究计划项目(QN2021072)
河北省自然科学基金资助项目(C2023204131)
河北农业大学人才引进项目(YJ2021003)。
关键词
多糖
环磷酰胺
提取纯化
减毒作用
协同增效
polysaccharides
cyclophosphamide
extraction and purification
toxicity reduction
synergistic effect
