摘要
目的:探究胺碘酮治疗急性心力衰竭合并心律失常的安全性和临床效果。方法:选取2021年7月-2022年10月东平县人民医院收治的急性心力衰竭合并心律失常患者60例为研究对象,随机分为对照组和观察组,各30例。对照组采用常规治疗,观察组在对照组基础上给予胺碘酮治疗。比较两组治疗总有效率、心功能指标[左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)]、不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.011);治疗后,两组LVEF水平升高,LVEDV、LVESV水平降低,观察组LVEF水平高于对照组,LVEDV、LVESV水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用胺碘酮治疗急性心力衰竭合并心律失常效果较好,可有效改善患者心功能,且用药较为安全。
Objective:To explore the safety and clinical effect of amiodarone in the treatment of acute heart failure complicated with arrhythmia.Methods:Sixty patients with acute heart failure complicated with arrhythmia admitted to Dongping County Peo-ple's Hospital from July 2021 to October 2022 were selected as the study objects,and randomly divided into control group and ob-servation group,with thirty patients in each group.The control group received conventional treatment,and the observation group received amiodarone treatment on the basis of the control group.The total effective rate,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)]and inci-dence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.011);after treatment,LVEF level in-creased,LVEDV and LVESV levels decreased,LVEF level in observation group was higher than control group,LVEDV and LVESV level was lower than control group,the difference was statistically significant(P<0.05);there was no significant differ-ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Amiodarone is effective in the treat-ment of acute heart failure complicated with arrhythmia,can effectively improve the cardiac function of patients,and the drug is relatively safe.
作者
董良
Dong Liang(Department of Cardiovascular Medicine,Tai'an Dongping County People's Hospital,Tai'an 271500,Shandong Province,China)
出处
《中外医药研究》
2024年第2期18-20,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
