摘要
目的:比较宫腔用交联透明质酸钠凝胶与宫内节育器联合雌孕激素应用于宫腔粘连分离术后的效果。方法:选取2022年1月-2023年6月浙江大学医学院附属妇产科医院诊治的中重度宫腔粘连患者166例为研究对象,随机分为对照组和研究组,各83例。对照组采用雌孕激素联合放置宫内节育器,研究组采用雌孕激素联合宫腔用交联透明质酸钠凝胶。比较两组围术期相关指标、宫腔粘连恢复情况、美国生育协会(AFS)评分及疗效。结果:研究组术后出血量少于对照组,月经复潮时间、腹痛持续时间、出血持续时间短于对照组,差异有统计学意义(P<0.001)。研究组再粘连程度轻于对照组,再粘连发生率低于对照组,差异有统计学意义(P<0.001)。治疗后,两组月经状况、粘连类型、粘连累及范围评分均较治疗前降低,研究组低于对照组,差异有统计学意义(P<0.05)。研究组疗效总有效率高于对照组,差异有统计学意义(P=0.008)。结论:宫腔粘连分离术后采用雌孕激素联合宫腔用交联透明质酸钠凝胶的应用效果较好,可降低再粘连发生率,减轻疾病严重程度,减少术后出血量,缩短月经复潮、腹痛、出血时间,提高疗效。
Objective:To compare the effect of cross-linked sodium hyaluronate gel for uterine cavity with intrauterine device combined with estrogen and progesterone applied after separation of uterine adhesions.Methods:One hundred and sixty-six pa-tients with moderate-to-severe uterine adhesions diagnosed and treated in the Obstetrics and Gynecology Hospital Affiliated to the School of Medicine of Zhejiang University from January 2022 to June 2023 were selected for the study,and were randomly di-vided into the control group and the study group,each with eighty-three cases.The control group used estrogen and progesterone combined with the placement of intrauterine device,and the study group used estrogen and progesterone combined with cross-linked sodium hyaluronate gel for the uterine cavity.The perioperative related indexes,recovery of uterine adhesions,American Fertility Society(AFS)score and efficacy were compared between the two groups.Results:The postoperative bleeding of the study group was less than that of the control group,and the time of menstrual resumption,the duration of abdominal pain,and the dura-tion of bleeding were shorter than that of the control group,with statistically significant differences(P<0.001).The degree of re-ad-hesion of the study group was lighter than that of the control group,and the incidence of re-adhesion was lower than that of the control group,with statistically significant differences(P<0.001).After treatment,the scores of menstrual status,adhesion type,and adhesion involvement range were lower in both groups than before treatment,and the study group was lower than the control group,with a statistically significant difference(P<0.05).The total effective rate of efficacy of the study group was higher than that of the control group,and the difference was statistically significant(P=0.008).Conclusion:The application of estrogen and proges-terone combined with cross-linked sodium hyaluronate gel for the uterine cavity after separation of uterine adhesions is more effec-tive,which can reduce the rate of re-adhesion,alleviate the severity of the disease,reduce the amount of postoperative bleeding,shorten the time of menstrual resumption,abdominal pain,and bleeding,and improve the efficacy of treatment.
作者
尚燕飞
Shang Yanfei(Department of Obstetrics and Gynecology,Obstetrics and Gynecology Hospital Affiliated to the School of Medicine of Zhejiang Uni-versity,Hangzhou 310003,Zhejiang Province,China)
出处
《中外医药研究》
2024年第2期27-29,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
雌孕激素
宫腔用交联透明质酸钠凝胶
宫腔粘连分离术
Estrogen and progesterone
Cross-linked sodium hyaluronate gel for uterine cavity
Separation of uterine adhesions
