摘要
目的 观察妊娠期梅毒对不良妊娠结局的影响。方法 将2017年6月-2022年6月在南京市第二医院分娩的妊娠合并梅毒的580例孕妇,分为A组(接受苄星青霉素治疗的梅毒孕妇,其中A1组孕期初次诊断梅毒感染并接受2个疗程苄星青霉素规范治疗的孕妇;A2梅毒螺旋体明胶凝集试验(TPPA)阳性、快速血浆反应素试验(RPR)阴性和血清固定的孕妇,既往接受规范治疗,孕期给予1个疗程苄星青霉素;A3 TPPA阳性、RPR阴性和血清固定的孕妇,既往接受规范治疗,孕期拒绝治疗)、B组(不规范治疗的梅毒孕妇)、C组(未治疗的梅毒孕妇)。比较A、B、C 3组间早产、低出生体质量、围产儿死亡及先天性梅毒儿发生率。结果 3组孕妇年龄、分娩方式和所生婴儿性别差异无统计学意义(P>0.05)。A、B、C 3组总不良妊娠结局的发生率为分别是11.39%(50/439)、24.59%(30/122)和63.16%(12/19),差异有统计学意义(P<0.05)。所有新生儿的血清梅毒抗体TPPA和RPR在18个月龄内均转为阴性。结论梅毒感染的孕妇接受2个疗程苄星青霉素治疗可减少不良妊娠结局的发生。
Objective To investigate the effects of treatment of syphilis during pregnancy on adverse pregnancy outcomes.Methods Totally 580 pregnant women with syphilis in Nanjing Second Hospital from June 2017 to June 2022 were divided into group A:Syphilis pregnant women who received benzathine penicillin treatment;group A1:pregnant women who were first diagnosed with syphilis infection during pregnancy and received two courses of benzathine penicillin;A2:Pregnant women with positive treponema pallidum particle assay(TPPA),negative Rapid Plasma reagin(RPR)and fixed serum should receive standard treatment in the past and one course of benzathine penicillin during pregnancy;A3:Pregnant women who are TPPA-positive,RPR-negative and serum-fixed shall receive standard treatment in the past and refuse therapy during pregnancy.The incidence of preterm birth,low birth weight,perinatal death,and congenital syphilis among groups A,B,and C were compared.Results There were no significant differences in age,mode of delivery,and sex of the babies in three groups(P>0.05).The incidence of total adverse pregnancy outcomes in groups A,B and C was 11.39%(50/439),24.59%(30/122),and 63.16%(12/19),respectively,and the difference was statistically significant(P<0.05).All neonates were converted to be negative with serum syphilis antibody within 18 months of age.Conclusion Two courses of benzathine penicillin in syphilis pregnancy can reduce the incidence of adverse pregnancy outcomes.
作者
季莹
华云晖
Ji Ying;Hua Yunhui(Nanjing Second Hospital,Nanjing 210003,Jiangsu,China)
出处
《中国中西医结合皮肤性病学杂志》
CAS
2024年第1期18-21,共4页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
梅毒
孕产妇
青霉素
妊娠结局
Syphilis
Pregnany
Penicillin
Pregnancy outcome
