摘要
目的 探讨红花逍遥片治疗乳腺增生症的疗效。方法 选取2021年3月至2022年3月邵阳学院附属第一医院收治的86例乳腺增生症患者作为研究对象,根据治疗方案不同分为观察组与对照组,各43例。对照组患者应用枸橼酸他莫昔芬片治疗,观察组患者应用红花逍遥片治疗。比较两组患者治疗前后性激素水平、治疗后中医证候积分、治疗有效率与不良反应发生率。结果 治疗前两组雌二醇、孕酮、黄体生成素水平比较差异无统计学意义(P>0.05);治疗后,与对照组比较,观察组雌二醇水平更低,孕酮与黄体生成素水平更高,差异有统计学意义(P<0.05)。观察组治疗后乳房肿块、胸闷胁胀、乳房胀痛、少气懒言、舌淡红苔薄白、脉弦细数积分显著低于对照组(P<0.05)。观察组治疗有效率高于对照组,用药期间不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 利用红花逍遥片治疗乳腺增生症可以显著改善性激素水平,缓解患者的不适症状,疗效更好,安全性更高。
Objective To explore the curative effect of Honghua Xiaoyao Tablets on mammary hyperplasia.Methods A total of 86 patients with breast hyperplasia admitted to the First Affiliated Hospital of Shaoyang University from March 2021 to March 2022 were selected as the study objects and divided into observation group and control group according to different treatment plans,with 43 cases in each group.The control group was treated with tamoxifen citrate tablets,and the observation group was treated with Honghua Xiaoyao tablets.The sex hormone level before and after treatment,TCM syndrome score after treatment,effective rate and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in estradiol,progesterone and luteinizing hormone levels between the two groups before treatment(P>0.05).After treatment,compared with the control group,the estradiol level in the observation group was lower,and the progesterone and luteinizing hormone levels were higher,with statistical significance(P<0.05).After treatment,breast mass,chest tightness and distension,breast distension and pain,little qi and lazy speech,light red tongue and thin white fur,pulse and string score in observation group were significantly lower than those in control group(P<0.05).The effective rate of treatment in the observation group was higher than that in the control group,and the incidence of adverse reactions during medication was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Honghua Xiaoyao tablets in the treatment of mammary hyperplasia can significantly improve the level of sex hormones,relieve the discomfort symptoms of patients,better efficacy,higher safety.
作者
谢明
曾子纯
XIE Ming;ZENG Zi-Chun(Department of Breast and Thyroid Surgery,The First Afiliated Hospital of Shaoyang University,Shaoyang 422000,China)
出处
《中国药物经济学》
2024年第2期47-49,56,共4页
China Journal of Pharmaceutical Economics
关键词
乳腺增生症
红花逍遥片
他莫昔芬
性激素
Mammary hyperplasia
Red flower free and unfettered film
Tamoxifen
Sex hormone
