摘要
目的分析乙型肝炎患者乙型肝炎病毒(HBV)-DNA定量检测与两对半检测结果的相关性,并观察不同病情HBV-DNA阳性率和两对半检测结果差异。方法选取江苏省泰兴市人民医院2021年4月至2023年4月收治的375例乙型肝炎患者病例为研究资料。比较不同乙肝两对半检测[乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)、乙肝e抗原(HBeAg)、乙肝e抗体(HBeAb)、乙肝核心抗体(HBcAb)]结果患者HBV-DNA定量检测结果差异,将患者根据HBV-DNA定量检测结果分为阳性组和阴性组,比较乙肝两对半结果差异,使用Pearson相关性分析;将患者根据疾病类型分为肝炎组、肝硬化组和肝癌组,比较三组患者乙肝两对半和HBV-DNA定量检测结果差异。结果不同乙肝两对半类型患者HBV-DNA阳性率比较,差异有统计学意义(P<0.05);HBV-DNA阳性组患者HBsAg、HBeAg水平高于HBV-DNA阴性组,HBsAb、HBeAb、HBcAb水平低于HBV-DNA阴性组,差异有统计学意义(P<0.05);HBsAg、HBeAg水平与HBV-DNA呈正相关(P<0.05),HBsAb、HBeAb、HBcAb水平与HBV-DNA呈负相关(P<0.05);不同疾病类型患者乙肝两对半类型HBV-DNA阳性率比较,差异有统计学意义(P<0.05),不同疾病类型患者HBV-DNA定量检测结果比较,差异有统计学意义(P<0.05)。结论乙型肝炎患者HBV-DNA定量检测与两对半检测结果有相关性,不同乙肝两对半类型间及不同疾病类型间HBV-DNA均有差异,HBV-DNA定量检测联合两对半检测可较好地反映病毒复制和疾病进展情况,为临床治疗提供指导。
Objective To analyze the correlation between the HBV-DNA quantification and serologic test results n patients with hepatitis B,and to observe the differences in the positive rates of hepatitis B virus(HBV)-DNA and the results of serologic tests in different diseases.Methods A total of 375 hepatitis B patients admitted to the Taixing People’s Hospital,Jiangsu Province from April 2021 to April 2023 were selected as the research data.The difference of HBA-DNA quantification test results of patients with different hepatitis B serologic test results(hepatitis B surface antigen[HBsAg],hepatitis B surface antibody[HBsAb],hepatitis B e antigen[HBeAg],hepatitis B e antibody[HBeAb],hepatitis B core antibody[HBcAb])was compared,and the patients were divided into a positive group and a negative group according to the HBV-DNA quantification test results.The difference of the hepatitis B serologic test was compared,and Pearson correlation analysis was used;The patients were divided into a hepatitis group,a cirrhosis group,and a liver cancer group according to the disease type,and the differences of hepatitis B serologic test types and the HBV-DNA quantification test results among the three groups were compared.Results The positive rate of HBV-DNA in patients with different hepatitis B serologic test models was compared,with statistically significant difference(P<0.05).The levels of HBsAg and HBeAg of patients in the HBV-DNA positive group were higher than those of patients in the HBV-DNA negative group,while the levels of HBsAb,HBeAb,and HBcAb were lower than those in the HBV-DNA negative group,with statistically significant differences(P<0.05).The levels of HBsAg and HBeAg were positively correlated with HBV-DNA(P<0.05),while the levels of HBsAb,HBeAb,and HBcAb were negatively correlated with HBV-DNA(P<0.05).The positive rate of types of hepatitis B serologic test in patients with different disease types were compared,with statistically significant difference(P<0.05),and the quantitative detection results of HBV-DNA in patients with different disease types was compared,with statistically significant difference(P<0.05).Conclusion The HBV-DNA quantification test in patients with hepatitis B is correlated with the serologic test results.There are differences in HBV-DNA between different hepatitis B serologic test models and between different diseases.The combination of HBV-DNA quantification test and serologic test can better reflect the situation of virus replication and disease progress and guide clinical treatment.
作者
陈静
金灿灿
周皓鹏
张茜蕙
梅辉
CHEN Jing;JIN Cancan;ZHOU Haopeng;ZHANG Xihui;MEI Hui(Laboratory Department,Taixing People’s Hospital,Jiangsu,Taizhou 225400,China)
出处
《中国医药科学》
2024年第5期161-164,168,共5页
China Medicine And Pharmacy
