摘要
目的探讨肝素结合蛋白(HBP)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)联合用于诊断早期脓毒症的效果及预后评估。方法选择2022年7月至2023年6月苏州市立医院收治的早期脓毒症患者72例作为观察组,选择同期住院的非感染疾病患者72例作为对照组,进行回顾性分析,检测HBP、PCT、hs-CRP指标,比较观察组患者与对照组体检者测定结果差异,分别计算单一指标及三项指标联合诊断脓毒症的灵敏度、特异度及准确度。另外结合观察组患者预后情况比较存活患者与死亡患者三项指标检测结果。结果观察组脓毒症患者HBP、PCT、hs-CRP水平高于对照组,差异有统计学意义(P<0.05)。三项指标联合诊断脓毒症的敏感度、准确度均高于单一指标检测,差异有统计学意义(P<0.05)。存活患者HBP、PCT、hs-CRP水平均低于死亡患者,差异有统计学意义(P<0.05)。结论临床诊断早期脓毒症可采用HBP、PCT、hs-CRP三项指标联合分析方式,具有较高的敏感度与准确度,且便于评估患者预后质量,值得推广。
Objective To explore the combined use of three indicators of heparin-binding protein(HBP),procalcitonin(PCT),and hypersensitive C-reactive protein(hs-CRP)in the diagnosis and prognosis assessment of early sepsis.Methods A total of 72 patients with early sepsis who were admitted to Suzhou Municipal Hospital for treatment from July 2022 to June 2023 were selected as the observation group,and 72 non-infectious disease patients who were hospitalized in the same hospital during the same period were selected as the control group.A retrospective analysis was conducted,and the indicators of HBP,PCT,and hs-CRP were tested.The differences in the test results between patients in the observation group and physical examiners in the control group were compared,and the sensitivity,specificity,and accuracy of a single indicator and a combination of three indicators for the diagnosis of sepsis were calculated,respectively.In addition,combined with the prognosis of patients in the observation group,the results of the three indicators of survivors and the dead were compared.Results The levels of HBP,PCT,and hs CRP in the observation group of sepsis patients were higher than those in the control group,with statistically significant differences(P<0.05).The sensitivity and accuracy of the combined diagnosis of sepsis using three indicators are higher than those of single indicator detection,with statistically significant differences(P<0.05).The levels of HBP,PCT,and hs CRP in surviving patients were lower than those in deceased patients,with statistically significant differences(P<0.05).Conclusion The analysis of a combination of three indicators of heparin-binding protein,procalcitonin,and high-sensitivity C-reactive protein can be used for clinical diagnosis of early sepsis,which has high sensitivity and accuracy and is convenient for assessing the quality of patient prognosis.Therefore,it is worth promoting.
作者
曾彬
ZENG Bin(Emergency Medicine Department of Suzhou Municipal Hospital Headquarters,Jiangsu,Suzhou 215002,China)
出处
《中国医药科学》
2024年第5期191-194,共4页
China Medicine And Pharmacy
关键词
肝素结合蛋白
降钙素原
超敏C反应蛋白
早期脓毒症
预后
Heparin-binding protein
Procalcitonin
Hypersensitive C-reactive protein
Early sepsis
Prognosis
