摘要
目的探讨血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)表达对甲状腺相关性眼病(TAO)患者的病情评估的价值。方法选取龙岩市第一医院内分泌科2022年1—12月收治的63例TAO患者为研究组,另选取同期健康体检者63例为对照组,检测所有患者的IL-6、TNF-α、sICAM-1指标和肝功能指标,然后进行比较。结果研究组患者IL-6、TNF-α、sICAM-1水平高于对照组,差异有统计学意义(P<0.05)。研究组TSH水平低于对照组组,差异有统计学意义(P<0.05);研究组FT3、FT4水平高于对照组,差异有统计学意义(P<0.05)。血清IL-6、TNF-α、sICAM-1与FT3、FT4均呈正相关(P<0.05)。结论血清IL-6、TNF-α、sICAM-1表达对TAO病情评估有一定的价值,利于预防和控制疾病。
Objective To explore expressions of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and soluble intercellular adhesion molecule-1(sICAM-1)in evaluating the condition of patients with thyroid-associated ophthalmopathy(TAO).Methods A total of 63 TAO patients admitted to the Department of Endocrinology of Longyan First Hospital from January 2022 to December 2022 were included in the study group.Additionally,63 health examination patients during the same period were selected as the control group.The indicators of IL-6,TNF-α,sICAM-1,and liver function indicators of all patients were tested and compared.Results The levels of IL-6,TNF-α,and sICAM-1 of patients in the study group were all higher than those of patients in the control group,with statistically significant differences(P<0.05).The TSH index in the study group was lower than that in the control group,with statistically significant difference(P<0.05).The FT3 and FT4 indicators in the study group were higher than those in the control group,with statistically significant differences(P<0.05).Serum IL-6,TNF-α,and sICAM-1 are positively correlated with FT3 and FT4(P<0.05).Conclusion The expressions of serum IL-6,TNF-α,and sICAM-1 have certain value in evaluating the condition of TAO,which is beneficial for preventing and controlling the disease.
作者
黄建青
陈阳
童艳
丘水林
魏雯
张凯萍
HUANG Jianqing;CHEN Yang;TONG Yan;QIU Shuilin;WEI Wen;ZHANG Kaiping(Department of Endocrinology,Longyan First Hospital,Fujian,Longyan 364000,China;Department of Ophthalmology,Longyan First Hospital,Fujian,Longyan 364000,China)
出处
《中国医药科学》
2024年第6期143-146,共4页
China Medicine And Pharmacy
基金
福建省龙岩市科技计划项目(2021LYF17032)。
