摘要
人体肠道内定居着大量的微生物群,他们参与机体免疫稳态的调节,并与缺血性脑卒中的发生发展密切相关。脑肠轴的发现将肠道与大脑联系在一起,在人类的健康与疾病过程中发挥重要作用。现综述脑肠轴的调节机制、卒中后肠道菌群及其代谢物的调节以及基于脑肠轴对缺血性脑卒中后的大脑和肠道免疫反应的可能机制。这些研究为探索卒中后肠道和大脑免疫治疗的新方向和改善脑卒中预后提供了重要意义。
It has been shown that the human gut is settled with a large microbiota,which is involved in the regulation of the body's immune homeostasis and is closely related to the development of ischaemic stroke.The discovery of the microbial-gut-brain axis links the gut to the brain and plays an important role in human health and disease processes.This paper reviews the regulatory mechanisms of the microbial-gut-brain axis,the modulation of gut flora and its metabolites after stroke,and the possible mechanisms of the brain-gut axis based on brain and gut immune responses after ischaemic stroke.These studies provide important implications for exploring new directions of gut and brain immunotherapy after stroke and improving stroke prognosis.
作者
徐玉洁
高娟
王井辉
任涵
王子文
耿硕
XU Yujie;GAO Juan;WANG Jinghui;REN Han;WANG Ziwen;GENG Shuo(Graduate School,Chengde Medical College,Chengde 067000,China;Department of Neurology,Baoding First Central Hospital,Baoding 071000,China;Graduate School of Hebei Medical University,Shijiazhuang 050000,China;Endocrine Laboratory,Baoding First Central Hospital,Baoding 071000,China)
出处
《医学研究与教育》
CAS
2024年第1期9-17,共9页
Medical Research and Education
基金
国家自然科学基金项目(32201393)。
关键词
缺血性脑卒中
肠道菌群
脑肠轴
免疫
ischaemic stroke
gut flora
microbe-gut-brain axis
immunity
