摘要
类淋巴系统(glymphatic system,GS)是脑内新发现的废物清除系统,GS的损伤与多种神经系统疾病密切相关。MRI因具有高度软组织分辨率及多模态成像的优点,被广泛运用于GS的成像研究中。以MRI为主的影像技术为GS的动力学、结构以及相关疾病的研究提供了重要依据。笔者将简要介绍GS解剖与生理功能,并对GS的成像技术及其在神经系统疾病中的应用进展进行综述,旨在提示GS功能障碍在神经影像学研究中的重要性并为GS相关神经系统疾病的诊治及预后提供帮助。
The glymphatic system(GS)is a recently discovered mechanism of brain waste elimination,and its disruption is strongly associated to a variety of neurological diseases.The GS has been widely studied using MRI because of its advantages of high soft tissue resolution and multimodal imaging.Providing a substantial basis for the research of the kinetics and structure of the GS and related diseases,MRI contributes as the principal imaging technique.The author will present an overview of the GS and highlight recent advances in MRI of the GS and their application in the investigation of neurological diseases,aiming to stress the importance of glymphatic dysfunction in neuroimaging investigations and provide help for the diagnosis,treatment and prognosis of neurological diseases related to the GS.
作者
沈文卓
李勇刚
SHEN Wenzhuo;LI Yonggang(College of Basic Medical Science,China Three Gorges University,Yichang 443002,China;Department of Radiology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第3期212-217,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
江苏省卫生与健康委员会重点科研项目(编号:K2023027)
江苏省研究型医院学会感染与炎症放射学会专委会科研基金项目(编号:GY202301)
苏州大学苏州医学院医学+X项目(编号:ML12203423)。
关键词
类淋巴系统
磁共振成像
扩散张量成像
神经系统疾病
glymphatic system
magnetic resonance imaging
diffusion tensor imaging
nervous system disease
