摘要
背景脑性瘫痪(简称脑瘫)患儿临床表现多样,国内大样本数据分析不同性别脑瘫患儿特征的研究不多。目的探究脑瘫患儿临床特征的性别差异。设计病例系列报告。方法回顾性收集2019年1月至2022年2月在郑州大学第三附属医院住院治疗的脑瘫患儿的一般资料、围生期危险因素和临床特征。主要结局指标脑瘫患儿临床特征的性别差异。结果共纳入486例脑瘫患儿,其中男323例,女163例。脑瘫男性患儿中剖宫产、早产儿、巨大儿的比例均明显高于女性患儿,而正常出生体重儿的比例明显低于女性患儿,脑瘫男性患儿中春季出生的比例明显低于女性患儿,冬季出生的比例明显高于女性患儿,差异均有统计学意义。脑瘫男性患儿在妊娠并发症、窒息、脑出血、新生儿缺血缺氧性脑病、低血糖的比例明显高于女性患儿,差异均有统计学意义;在粗大运动功能分级系统(GMFCS)分级多组间比较中Ⅳ、Ⅴ级的比例明显高于女性患儿,在脑瘫患儿头颅MR分类系统多组间比较中白质异常的比例脑瘫男性患儿明显高于女性患儿,差异均有统计学意义。结论脑瘫患儿的部分临床特征存在性别差异,脑瘫患儿中以男性为主且严重程度较女性重。
Background The clinical manifestations of children with cerebral palsy are diverse,and there are few studies analyzing the characteristics of children with cerebral palsy of different genders with large sample data in China.Objective To explore the gender differences in clinical data of children with cerebral palsy.Design Case series report.Methods General information,perinatal risk factors,and clinical features of children with cerebral palsy who were hospitalized in the Third Affiliated Hospital of Zhengzhou University from January 2019 to February 2022 were retrospectively collected.Main outcome measures Gender differences in clinical features of children with cerebral palsy.Results A total of 486 children with cerebral palsy were included,including 323 males and 163 females.The proportion of cesarean section,premature infants and macrosomia in males was significantly higher than that in females,while the proportion of normal birth weight children was significantly lower than that in females.In the comparison of birth seasons between groups,the proportion of males born in spring was significantly lower than that of females,while the proportion of winter births was significantly higher than that of females.The proportion of pregnancy complication,asphyxia,cerebral hemorrhage,hypoxic-ischemic encephalopathy and hypoglycemia in males was significantly higher than that in females.The proportion of grade IV and V in the Gross Motor Function Classification System was significantly higher than that in females,and the proportion of abnormal white matter in MRI classification was significantly higher than that in female children.Differences were statistically significant across all comparisons.Conclusion There are gender differences in some clinical data of children with cerebral palsy.Most of the children with cerebral palsy are males and the severity is more serious than that of females.
作者
牛国辉
张萌萌
崔博
朱登纳
李林琛
夏冰
李停停
谢加阳
NIU Guohui;ZHANG Mengmeng;CUI Bo;ZHU Dengna;LI Linchen;XIA Bing;LI Tingting;XIE Jiayang(Department of Child Rehabilitation,Third Affiliated Hospital of Zhengzhou University,Key Laboratory of Pediatric Brain Injury,Zhengzhou Key Laboratory for Prevention and Treatment of Childhood Cerebral Palsy,Zhengzhou 450052,China)
出处
《中国循证儿科杂志》
CSCD
北大核心
2024年第1期47-51,共5页
Chinese Journal of Evidence Based Pediatrics
基金
国家卫生健康委医院管理研究所项目:ZDSFY-2018-JYB-10
河南省医学科技攻关省部共建项目:SBGJ2018047。
关键词
脑性瘫痪
性别
危险因素
儿童
Cerebral palsy
Gender
Risk factors
Children
