摘要
目的:探讨急性前循环大血管闭塞性脑梗死(ALVS)患者在急诊血管内治疗术后血管再通后血清视椎蛋白样蛋白1(VILIP-1)、水通道蛋白-4(AQP4)、网膜素-1(Omentin-1)的表达和临床意义。方法:选取154例我院2019年9月-2022年9月就诊的ALVS患者,入院后均行血管内治疗术,根据术后90d改良Rankin(mRS)评分分为预后良好组116(75.32%)、预后不良组38例(24.68%),比较两组临床资料及术前、术后1个月Omentin-1、AQP4、VILIP-1的表达水平,Pearson分析术后1个月上述指标与mRS评分相关性,Logistic回归方程分析预后影响因素,并分析其预测价值。结果:与预后良好组比较,预后不良组术前血清VILIP-1、AQP4水平较低(P<0.05),Omentin-1水平较高(P<0.05),术后1个月血清VILIP-1、AQP4水平较低(P<0.05),Omentin-1水平较高(P<0.05),且术后1个月更为显著(P<0.05);术后1个月血清VILIP-1、AQP4水平与mRS评分呈正相关,Omentin-1水平与mRS评分呈负相关(P<0.05);VILIP-1、AQP4为术后90d预后不良危险因素,Omentin-1为预后不良保护因素(P<0.05);与低危组比较,高危组术后90d不良预后发生率高于低危组(P<0.05)。结论:血清VILIP-1、AQP4、Omentin-1水平为ALVS患者血管内治疗术后血管再通预后的重要影响因素,为临床早期评估和预测预后提供可靠依据。
Objective:To investigate the expression and clinical significance of serum opsin-like protein 1(VILIP-1),aquaporin-4(AQP4)and omentin-1(Omentin-1)in patients with acute anterior circulation large vessel occlusive cerebral infarction(ALVS).Methods:A total of 154 patients with ALVS who were treated in our hospital from September 2019 to September 2022 were selected and received endovascular treatment fter admission.According to the modified Rankin(mRS)score at 90 days after surgery,they were divided into a good prognosis group 116(75.32%)in the good group and 38(24.68%)in the poor prognosis group.Compare the clinical data and the expression of serum Omentin-1,AQP4,and VILIP-1 between the two groups before and 1 month after surgery,Pearson analysis of the correlation between the above indicators and mRS score at 1 month after surgery,Logistic regression equation analysis of prognostic factors,and analysis of the predicted value.Results:Compared with the group with good prognosis,the group with poor prognosis had lower preoperative serum levels of VILIP-1 and AQP4(P<0.05),higher levels of Omentin-1(P<0.05),lower serum levels of VILIP-1 and AQP4(P<0.05),and higher levels of Omentin-1(P<0.05)at 1 month after surgery,and more significantly at 1 month after surgery(P<0.05);One month after operation,serum VILIP-1 and AQP4 levels were positively correlated with mRS score,and Omentin-1 level was negatively correlated with mRS score(P<0.05);VILIP-1 and AQP4 were risk factors for poor prognosis at 90 days after operation,and Omentin-1 was a protective factor for poor prognosis(P<0.05);Compared with the low-risk group,the incidence of adverse prognosis at 90 days in the high-risk group was higher than that in the low-risk group(P<0.05).Conclusion:Serum levels of VILIP-1,AQP4,and Omentin-1 are important influencing factors for the prognosis of ALVS patients after endovascular therapy.They provide reliable clinical evaluation and prediction of prognosis,as wellas formulate follow-up treatment plans.
作者
任晓慧
荆丽娜
牛萌
REN Xiao-hui;JING Li-na;NIU Meng(Neurology Department of Zhengzhou Third People's Hospital,Henan Zhengzhou 450000)
出处
《医学检验与临床》
2024年第2期13-17,共5页
Medical Laboratory Science and Clinics
