摘要
目的探究血清、卵泡液中人趋化素(Chemerin)水平预测多囊卵巢综合征(PCOS)患者妊娠结局的价值。方法观察组(PCOS组)为2021年7月至2023年1月在我院接受体外受精-胚胎移植(IVF-ET)治疗的PCOS不孕患者106例,对照组为88例同期非PCOS患者。比较两组血清、卵泡液中Chemerin水平;PCOS组临床妊娠患者进一步细分为妊娠结局良好组及妊娠结局不良组,ROC曲线分析Chemerin预测PCOS妊娠结局的价值。结果(1)PCOS组患者血清、卵泡液中Chemerin水平均高于对照组,差异有统计学意义(P<0.05);(2)PCOS患者妊娠结局不良组血清、卵泡液中Chemerin水平均高于妊娠良好组,差异有统计学意义(P<0.05);(3)ROC曲线分析结果显示,单独检测血清、卵泡液中Chemerin水平,其中血清中Chemerin水平的AUC是0.868,卵泡液中Chemerin水平的AUC是0.828,联合检测血清、卵泡液中Chemerin AUC最大0.905。结论PCOS患者血清、卵泡液中Chemerin水平均升高,妊娠结局不良组血清、卵泡液中Chemerin水平升高更明显,提示Chemerin与PCOS疾病的发生发展密切相关,可作为预测PCOS患者妊娠结局的评估指标。
Objective To investigate the predictive value of combined chemerin levels in serum and follicular fluid for pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A total of 106 infertile patients with PCOS who underwent in vitro fertilization-embryo transfer(IVF-ET)in our hospital form July 2021 to July 2023 were selected as the study groups(PCOS Group).In the same period,A total of 88 patients with non-PCOS were selected as the control group.chemerin levels in serum and follicular fluid were compared between the two groups.The PCOS group was further divided into a good pregnancy outcome group and a poor pregnancy outcome group based on pregnancy outcomes.ROC curve analysis was performed to evaluate the predictive value of chemerin levels in serum and follicular fluid for PCOS.Results(1)chemerin levels in serum and follicular fluid in the PCOS group were higher than those in the control group(P<0.05),(2)In the poor pregnancy outcome group,chemerin levels in serum and follicular fluid were higher than in the good pregnancy outcome group(P<0.05),(3)ROC curve showed that the area under the curve of chemerin levels in serum and follicular fluid was 0.868 and 0.828,the AUC of combined chemerin levels in serum and follicular fluid was 0.905.Conclusion The levels of chemerin in serum and follicular fluid of PCOS patients were increased,In the group with poor pregnancy outcomes,chemerin levels in serum and follicular fluid are higher,This suggests that chemerin levels are closely related to the occurrence and development of PCOS and can serve as evaluation indicators for predicting pregnancy outcomes in PCOS patients.
作者
赵文华
ZHAO Wenhua(Reproductive Medicine Center,Inner Mongolia People's Hospital,Hohhot 010017 China)
出处
《内蒙古医学杂志》
2024年第1期31-34,共4页
Inner Mongolia Medical Journal
基金
内蒙古自治区卫生健康科技计划项目(编号:202202025)。
