摘要
目的研究使用喹硫平治疗的精神分裂症患者其喹硫平血药浓度水平与甲状腺功能指标之间的相关性,探讨喹硫平血药浓度影响甲状腺功能减低的临床意义。方法选取2018年1月至2019年12月南宁市第五人民医院收治的142例精神分裂症患者作为研究对象,收集患者一般资料及实验室检查指标,以促甲状腺激素(TSH)、三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))作为甲状腺功能指标,分析喹硫平血药浓度与甲状腺功能指标之间的关系。结果喹硫平治疗后,TSH水平较治疗前上升,T_(3)、T_(4)、FT_(3)、FT_(4)水平较治疗前下降,差异有统计学意义(P<0.05)。Pearson相关性分析发现,喹硫平血药浓度与TSH水平呈正相关(P<0.05),与T_(4)、FT_(4)水平呈负相关(P<0.05)。多元线性回归分析结果显示,喹硫平血药浓度是精神分裂症患者喹硫平治疗后TSH水平升高的独立影响因素(P<0.05)。ROC曲线分析显示,喹硫平血药浓度影响甲状腺功能减低的灵敏度和特异度分别为50%和81.5%,AUC为0.669。结论喹硫平治疗的精神分裂症患者血清甲状腺激素水平与喹硫平血药浓度相关,喹硫平血药浓度会引起精神分裂症患者甲状腺功能减低,提示对使用喹硫平治疗的精神分裂症患者应监测其血药浓度及血清甲状腺激素水平。
Objective To investigate the correlation between the serum concentration of Quetiapine and thyroid function index in patients with schizophrenia treated with Quetiapine,and to explore the clinical significance of serum concentration of Quetiapine on thyroid function reduction.Methods A total of 142 patients with schizophrenia admitted to the Nanning Fifth People's Hospital from January 2018 to December 2019 were selected as the research subjects.General information and laboratory examination indicators of the patients were collected.Thyroid stimulating hormone(TSH),triiodothyronine(T_(3)),thyroxine(T_(4)),free triiodothyronine(FT_(3))and free thyroxine(FT_(4))were used as thyroid function indexes to analyze the relationship between serum Quetiapine concentration and thyroid function.Results After Quetiapine treatment,TSH level increased,T_(3),T_(4),FT_(3) and FT_(4) levels decreased compared with treatment before(P<0.05).Pearson correlation analysis showed that serum Quetiapine concentration was positively correlated with TSH level(P<0.05),and negatively correlated with T_(4) and FT_(4) levels(P<0.05).The analysis of the ROC curve showed the sensitivity and specificity of Quetiapine on thyroid function reduction were 50%and 81.5%,respectively,and the AUC was 0.669.Conclusion Serum thyroid hormone levels in patients with schizophrenia treated with Quetiapine are correlated with serum concentration of Quetiapine,which can cause reduced thyroid function,suggesting that blood concentration and serum thyroid hormone levels should be monitored in patients with schizophrenia treated with Quetiapine.
作者
滕君媚
卢丹玉
张超
姚家伟
陆喜建
秦雪
TENG Junmei;LU Danyu;ZHANG Chao;YAO Jiawei;LU Xijian;QIN Xue(Clinical Laboratory,the First Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning530021,China;Clinical Laboratory,Nanning Fifth People's Hospital,Guangxi Zhuang Autonomous Region,Nanning530002,China)
出处
《中国当代医药》
CAS
2024年第7期140-144,共5页
China Modern Medicine
关键词
精神分裂症
喹硫平
血药浓度
甲状腺激素
Schizophrenia
Quetiapine
Blood concentration
Thyroid hormone
