摘要
目的 探讨血必净注射液联合沙库巴曲缬沙坦钠片治疗急性心肌梗死后心力衰竭患者的临床效果。方法 将76例急性心肌梗死后心力衰竭患者随机分为对照组和研究组各38例。两组患者入院均行经皮冠状动脉介入手术,同时对照组给予沙库巴曲缬沙坦钠片治疗,研究组给予血必净注射液联合沙库巴曲缬沙坦钠片治疗。比较两组患者的心功能指标及治疗期间的不良反应。结果 治疗12 d后,研究组左心室射血分数(LVEF)高于对照组,N端脑钠肽前体(NT-proBNP)水平低于对照组(P <0.05)。治疗期间,两组患者不良反应发生率(10.53%vs. 13.16%)比较,差异无统计学意义(P>0.05)。结论 血必净注射液联合沙库巴曲缬沙坦钠片治疗可明显改善急性心肌梗死后心力衰竭患者的心功能,且安全性较高。
Objective To explore the clinical effect of Xuebijing injection combined with sacubitril valsartan sodium tablets in the treatment of patients with heart failure after acute myocardial infarction.Methods 76 patients with heart failure after acute myocardial infarction were randomly divided into control group and study group,with 38 cases in each group.Both groups were treated with percutaneous coronary intervention.The control group was treated with sacubitril valsartan sodium tablets,and the study group was treated with Xuebijing injection combined with sacubitril valsartan sodium tablets.The cardiac function indicators and adverse reactions were compared between the two groups.Results After 12 days of treatment,the left ventricular ejection fraction(LVEF)of the study group was higher than that of the control group,and the N-terminal pro-brain natriuretic peptide(NT-proBNP)level was lower than that of the control group(P<0.05).During the treatment,no statistical difference was found in the incidence of adverse reactions(10.53%vs.13.16%)between the two groups(P>0.05).Conclusions Xuebijing injection combined with sacubitril valsartan sodium tablets in the treatment of heart failure after acute myocardial infarction can significantly improve the cardiac function of patients with higher safety.
作者
卢杏
张学平
卢鹏飞
刘志强
LU Xing;ZHANG Xueping;LU Pengfei;LIU Zhiqiang(Department of Cardiovascular Medicine,Xinxiang Central Hospital,Xinxiang 453000,China)
出处
《临床医学工程》
2024年第3期283-284,共2页
Clinical Medicine & Engineering
关键词
急性心肌梗死后心力衰竭
沙库巴曲缬沙坦钠片
血必净注射液
心功能
不良反应
Heart failure after acute myocardial infarction
Sacubitril valsartan sodium tablets
Xuebijing injection
Cardiac function
Adverse reaction
