摘要
目的:研究重组人干扰素 α2B 凝胶辅助治疗宫颈环形电切术术后创面修复及阴道微生态的影响.方法:以我院 2020 年 6 月至 2022 年 11 月收治的 118 例行宫颈环形电切术治疗的宫颈糜烂患者,随机分为对照组、联合组,各 59 例.对照组采用保妇康栓治疗,联合组采用重组人干扰素α2B凝胶辅助保妇康栓治疗.比较两组治疗36 d后相关指标变化情况;采用型微循环观察仪宫颈微循环指标,采用酶联免疫吸附法测定阴道灌洗液相关免疫炎症因子干扰素-γ(Interferon-γ,INF-γ)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、Toll样受体2(Toll like receptor 2,TLR2)水平,采用放射免疫法测定分泌型免疫球蛋白(Secretory immunoglobulin,sIgA)水平,且进行比较;并记录术后并发症发生率.结果:与治疗前相比,两组阴道排液时间、阴道流血时间、创面愈合时间、血性白带消失时间均明显降低,其中联合组更为显著(P<0.05);与治疗前相比,两组毛细血管管径、微血管管径、局部血流灌注均明显升高,其中联合组更为显著(P<0.05);与治疗前相比,两组阴道灌洗液INF-γ水平均明显升高,TNF-α、TLR2、sIgA水平均明显降低,其中联合组更为显著(P<0.05);与治疗前相比,两组术后并发症总发生率均明显降低,其中联合组更为显著(P<0.05).结论:重组人干扰素α2B凝胶辅助治疗宫颈糜烂术后患者可有效缓解临床症状,改善阴道微循环,减轻炎症反应,且降低术后并发症.
Objective:To study the effects of recombinant human interferonα2B gel on wound repair and vaginal microecology after cervical annular electrotomy.Method:A total of 118 patients with cervical erosion who underwent cervical ring electrotomy treated in our hospital from June 2020 to November 2022 were randomly divided into control group and combination group,with 59 cases in each group.The control group was treated with Baofukang Shuan,and the combination group was treated with recombinant human interferonα2B gel assisted with Baofukang Shuan.The control group was treated with Baofukang Shuan,and the combination group was treated with recombinant human interferonα2B gel assisted with Baofukang Shuan.The changes of related indexes were compared between the two groups after 36 days of treatment.Cervical microcirculation indicators Interferon-γ(INF-γ)and Tumor Necrosis Factor-α(TNF-α)were used to detect vaginal lavage fluid by enzyme-linked immunosorbent assay(ELISA).and Toll like receptor 2(TLR2)levels,Secretory immunoglobulin(sIgA)levels were measured by radioimmunoassay and compared.The incidence of postoperative complications was recorded.Results:Compared with before treatment,vaginal drainage time,vaginal bleeding time,wound healing time and hemorrhagic leucorrhea disappearance time were significantly decreased in 2 groups,especially in combination group(P<0.05);compared with before treatment,capillary tube diameter,microvascular tube diameter and local blood perfusion were significantly increased in 2 groups,especially in combination group(P<0.05);INF-γlevels were significantly increased in both groups compared with before treatment,and TNF-α,TLR2 and sIgA levels were significantly decreased in both groups,especially in combination group(P<0.05);compared with before treatment,the total incidence of postoperative complications was significantly decreased in both groups,especially in combination group(P<0.05).Conclusion:Recombinant human interferon alpha 2B gel can effectively relieve clinical symptoms,improve vaginal microcirculation,reduce inflammation and reduce postoperative complications.
作者
李瑞升
纪妹
孙辉
Li Rui-sheng;Ji Mei;Sun Hui(Department of Obstetrics and Gynecology,Sheqi County Health School Affiliated Hospital,Sheqi 473300,Henan,China;Department ofGynecology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Gynecology,Nanyang CentralHospital,Nanyang 473000,Henan,China)
出处
《四川生理科学杂志》
2024年第3期517-519,550,共4页
Sichuan Journal of Physiological Sciences
关键词
重组人干扰素α2B凝胶
保妇康
宫颈环形电切术
阴道微生态
Recombinant human interferon alpha 2B gel
Health care for women
Cervical annular electrotomy
Vaginal microecology
