摘要
目的 探讨多囊卵巢综合征(PCOS)患者血清硫氧还蛋白相互作用蛋白(TXNIP)、可溶性分化簇36(sCD36)水平变化及意义。方法 选取124例PCOS患者为PCOS组,另选取同期117名体检健康女性为对照组。收集所有研究对象糖脂代谢指标[空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、稳态模型评估(HOMA)-IR,采用酶联免疫吸附法检测血清TXNIP、sCD36。通过Pearson/Spearman相关性分析法分析PCOS患者血清TXNIP、sCD36水平与糖脂代谢指标、HOMA-IR的相关性,多因素Logistic回归分析血清TXNIP、sCD36水平与PCOS的关系,采用受试者工作特征(ROC)曲线分析血清TXNIP、sCD36水平对PCOS的诊断价值。结果 与对照组相比,PCOS组FPG、FINS、TC、TG、LDL-C、HOMA-IR、TXNIP、sCD36水平升高,HDL-C水平降低(P均<0.05)。Pearson/Spearman相关性分析显示,PCOS患者血清TXNIP、sCD36与FPG、FINS、TC、TG、LDL-C、HOMA-IR呈正相关(r分别为0.546、0.563、0.605、0.580、0.565、0.662和0.593、0.525、0.616、0.513、0.598、0.683,P均<0.05),与HDL-C呈负相关(r分别为-0.551、-0.545,P均<0.05)。多因素Logistic回归分析显示,校正糖脂代谢指标和HOMA-IR后,血清TXNIP(OR=1.047,95%CI:1.017~1.078)、sCD36(OR=1.475,95%CI:1.165~1.868)水平升高为PCOS的独立危险因素(P均<0.05)。ROC曲线分析显示,血清TXNIP、sCD36水平联合(AUC=0.914,95%CI:0.872~0.946)诊断PCOS的曲线下面积(AUC)大于血清TXNIP(AUC=0.822,95%CI:0.768~0.868)、sCD36(AUC=0.811,95%CI:0.755~0.858)水平单独诊断(P均<0.05)。结论 PCOS患者血清TXNIP、sCD36水平升高,且与糖脂代谢紊乱和IR有关;血清TXNIP、sCD36联合检测对PCOS有较高诊断价值。
Objective To investigate the changes in levels of serum thioredoxin-interacting protein(TXNIP) and soluble cluster of differentiation 36(sCD36) in patients with polycystic ovary syndrome(PCOS) and their clinical significance.Methods Totally 124 patients with PCOS were selected as the PCOS group,and another 117 healthy women with physical examination during the same period were selected as the control group.Glycolipid metabolic indices [fasting blood glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)] and homeostasis model assessment of insulin resistance(HOMA-IR) were collected from all the study subjects,and the levels of serum TXNIP,and sCD36 were measured by enzyme-linked immunosorbent assay.Pearson/Spearman correlation analysis was used to analyze the correlation of serum TXNIP and sCD36 levels with glucose-lipid metabolism indexes and HOMA-IR in patients with PCOS,multifactorial Logistic regression analysis was used to analyze the relationship between serum TXNIP and sCD36 levels and PCOS,and receiver operating characteristic(ROC) curves were used to analyze the diagnostic value of serum TXNIP and sCD36 levels for PCOS.Results Compared with the control group,the PCOS group had increased levels of FPG,FINS,TC,TG,LDL-C,HOMA-IR,TXNIP,and sCD36,and decreased level of HDL-C(all P<0.05).Pearson/Spearman correlation analysis showed that serum TXNIP and sCD36 levels were positively correlated with FPG,FINS,TC,TG,LDL-C,and HOMA-IR in patients with PCOS(r=0.546,0.563,0.605,0.580,0.565,0.662 and 0.593,0.525,0.616,0.513,0.598,0.683,respectively;all P<0.05) and were negatively correlated with HDL-C(r=-0.551,-0.545,respectively,all P<0.05).Multifactorial Logistic regression analysis showed that elevated serum TXNIP(OR=1.047,95% CI:1.017 to 1.078) and sCD36(OR=1.475,95% CI:1.165 to 1.868) levels were independent risk factors for PCOS after correction for glycolipid metabolism indexes and HOMA-IR(all P<0.05).ROC curve analysis showed that the area under the curve(AUC) of combination of serum TXNIP and sCD36 levels in the diagnosis of PCOS(AUC=0.914,95% CI:0.872 to 0.946) was greater than that of serum TXNIP(AUC=0.822,95% CI:0.768 to 0.868) and sCD36(AUC=0.811,the 95% CI:0.755 to 0.858) alone(both P<0.05).Conclusion Elevated serum TXNIP and sCD36 levels in patients with PCOS are associated with disorders of glycolipid metabolism and IR,and the combination detection of serum TXNIP and sCD36 levels has a high diagnostic value for PCOS.
作者
钱瑛
毛雅婷
曾苏婷
QIAN Ying;MAO Yating;ZENG Suting(Department of Premarital and Pregnancy Health,Maternity and Child Health Care Hospital Affiliated to Nantong University,Nantong 226000,China)
出处
《山东医药》
CAS
2024年第10期31-35,共5页
Shandong Medical Journal
基金
江苏省卫生健康委项目(JH19137)。
关键词
多囊卵巢综合征
硫氧还蛋白相互作用蛋白
可溶性分化簇36
糖脂代谢
胰岛素抵抗
polycystic ovary syndrome
thioredoxin-interacting protein
soluble differentiation cluster 36
glucolip-id metabolism
insulin resistance
