摘要
目的分析血清氧化低密度脂蛋白(ox-LDL)与多囊卵巢综合征(PCOS)不孕患者临床妊娠结局的关系。方法采用前瞻性队列研究方法连续收集2020年1月至2021年12月承德市中心医院诊治的155例PCOS不孕患者作为研究对象。记录患者的妊娠成功率,记录患者入组时临床资料及基线性激素指标、胰岛素抵抗相关指标、血清ox-LDL水平。根据血清ox-LDL水平分为高水平组(n=85)和低水平组(n=70)。分析血清ox-LDL与PCOS不孕患者临床妊娠结局的相关性。结果155例PCOS不孕患者中有34例成功妊娠,临床妊娠率为21.94%。高水平组临床妊娠成功率低于低水平组,稳态模型胰岛素抵抗指数(HOMA-IR)高于低水平组,差异具有统计学意义(P<0.05)。Logistic回归分析显示,PCOS不孕患者血清ox-LDL、HOMA-IR和甘油三酯(TG)表达上调是导致PCOS不孕患者临床妊娠失败的危险因素(P<0.05)。Pearson相关性检验显示,血清ox-LDL水平与PCOS不孕患者HOMA-IR和TG呈正相关(r>0,P<0.05)。受试者工作特征(ROC)曲线显示,血清ox-LDL水平预测PCOS不孕患者临床妊娠结局的曲线下面积(AUC)为0.806;当血清ox-LDL临界值达498.09μg/L时,患者发生临床妊娠失败风险较高。结论PCOS不孕患者临床妊娠结局与血清ox-LDL升高有关,早期检测有助于预测临床妊娠失败的风险,其可作为辅助预测指标。
Objective To analyze the correlation between serum oxidation low-density lipoprotein(ox-LDL)and clinical pregnancy outcomes in infertile patients with polycystic ovarian syndrome(PCOS).Methods A prospective cohort study method was used to continuously collect 155 cases of PCOS infertility patients treated at Chengde Central Hospital from January 2020 to December 2021 as the study subjects.The pregnancy success rate of the patients was recorded,and the clinical data,baseline sex hormone indexes,insulin resistance related indexes and serum ox-LDL levels were recorded when enrolled.According to the level of serum ox-LDL,the patients were divided into high-level group(n=85)and low-level group(n=70).The correlation between serum ox-LDL and clinical pregnancy outcome in infertile patients with PCOS were analyzed.Results Among 155 cases of PCOS infertility,34 cases were successfully pregnant,with a clinical pregnancy rate of 21.94%.The clinical pregnancy success rate of the high-level group was lower than that of the low-level group,and the homeostasis model insulin resistance index(HOMA-IR)was higher than that of the low-level group,with a statistically significant difference(P<0.05).According to Logistic regression analysis,upregulation of serum ox-LDL,HOMA-IR,and triglycerides(TG)expression in PCOS infertility patients were risk factors for clinical pregnancy failure(P<0.05).According to Pearson correlation test,serum ox-LDL levels were positively correlated with HOMA-IR and TG in infertile patients with PCOS(r>0,P<0.05).The receiver operating characteristic(ROC)curve showed the area under ROC curve(AUC)of serum ox-LDL level predicting the clinical pregnancy outcome of PCOS infertile patients was 0.806.When the serum ox-LDL threshold reached 498.09μg/L,the risk of clinical pregnancy failure in patients was higher.Conclusions The clinical pregnancy outcome of PCOS infertility patients is related to an increase in serum ox-LDL,and early detection can help predict the risk of clinical pregnancy failure and can be served as an auxiliary predictive indicator.
作者
寇伟鑫
司凡
高晓丽
陈妍
孙萌
许丽丽
陆宏艳
KOU Weixin;SI Fan;GAO Xiaoli;CHEN Yan;SUN Meng;XU Lili;LU Hongyan(Operation Room,Chengde Central Hospital,Chengde 067000,Hebei,China;Department ofReproductive Medicine,Chengde Central Hospital,Chengde 067000,Hebei,China;Department of Health Education,Chengde Center for Disease Control and Prevention,Chengde 067000,Hebei,China)
出处
《中国性科学》
2024年第3期87-91,共5页
Chinese Journal of Human Sexuality
基金
承德市科学技术研究与发展课题计划(202102A004)。
关键词
多囊卵巢综合征
不孕症
氧化低密度脂蛋白
妊娠结局
Polycystic ovarian syndrome
Infertility
Oxidation low-density lipoprotein
Pregnancy outcomes
