摘要
目的:研究系统性红斑狼疮(SLE)患者心外膜脂肪组织厚度(EFT)的改变,并探讨其与心脏彩超参数及心血管疾病(CVD)传统危险因素的相关性。方法:纳入2019年10月至2021年10月于我院住院的SLE患者作为病例组,同期健康人群作为对照组,测量2组的EFT,根据EFT是否增厚将SLE患者分为增厚组及不增厚组,比较2组炎症指标、心脏彩超参数及CVD传统危险因素之间的差异,并应用Logistic回归分析寻找EFT的危险因素。结果:SLE组患者的EFT[4.40(2.60)mm]较对照组[3.10(1.60)mm]显著增厚(P<0.001)。病例组患者中EFT增厚者占42.0%(76/131),对照组EFT增厚者仅占9.5%(9/95)。病例组中EFT增厚组与不增厚组比较结果显示,EFT增厚组的年龄、体质量指数(BMI)、左心房直径(LAD)、右心室内径(RVD)、室间隔厚度(IVST)、左心室后壁厚度(LVPWT)及颈动脉内膜中层厚度(CIMT)均显著高于不增厚组。EFT与年龄、病程、BMI、甘油三酯、低密度脂蛋白、LAD、RVD、IVST、LVPWT及CIMT等呈正相关。Logistic回归分析显示LVPWT增加是EFT增厚的危险因素。结论:SLE患者的EFT增厚与心脏结构或功能参数的改变相关,提示应对EFT增厚及心脏结构或功能参数异常的SLE患者进一步筛查心血管病变的危险因素。
Objective:To investigate the change of epicardial fat thickness(EFT)in patients with systemic lupus erythematosus(SLE)and its correlation with cardiac ultrasound parameters and traditional cardiovascular risk factors.Methods:SLE patients admitted to Rheumatology and Immunology Department of the First Affiliated Hospital of Jinan University from October 2019 to October 2021 were included as the case group,and healthy subjects in the same period were included as the control group.EFT was measured in both groups.SLE patients were divided into two subgroups according to whether EFT was thickened.The differences in inflammatory indicators,cardiac ultrasound parameters and traditional cardiovascular risk factors between the two subgroups were compared.Logistic regression analysis was used to explore the risk factors for EFT thickening.Results:The EFT of SLE patients was significantly thicker than that of the control group[4.40(2.60)mm vs.3.10(1.60)mm,P<0.001].EFT thickening occurred in 42.0%(76/131)of SLE patients and 9.5%(9/95)of healthy controls.The age,body mass index(BMI),left atrial diameter(LAD),right ventricular inner diameter(RVD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT)and carotid intima-media thickness(CIMT)in the EFT thickening group were significantly higher than those in the non-thickening group.EFT was positively correlated with age,disease course,BMI,triglyceride,low-density lipoprotein,LAD,RVD,IVST,LVPWT and CIMT.Logistic regression analysis demonstrated that increased LVPWT was a risk factor for EFT thickening.Conclusion:EFT thickening in SLE patients is associated with changes in cardiac structural or functional parameters,suggesting that further screening for cardiovascular risk factors should be conducted in SLE patients with increased EFT and abnormal cardiac structure or functional parameters.
作者
李朝霞
黎晓萱
徐春雪
徐宏贵
周毅
LI Zhaoxia;LI Xiaoxuan;XU Chunxue;XU Honggui;ZHOU Yi(Rheumatology and Immunology Department,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Department of Ultrasound,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China;Department of Cardiology,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China)
出处
《暨南大学学报（自然科学与医学版）》
CAS
北大核心
2024年第1期31-37,共7页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广州市基础研究计划基础与应用基础研究项目(2023A04J1916)
暨南大学中央高校基本科研业务费项目(自然科学类)(21622311)。
