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肥胖大鼠低氧训练中MDA、GSH-Px与瘦素相关性研究

Study on the Relationship Among Leptin and MDA,GSH-Px of the Obesity Rats Under Hypoxic Training
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摘要 为明确不同模式低氧训练对肥胖大鼠自由基代谢的影响,探讨低氧训练过程中自由基代谢与瘦素敏感性的关系。建立肥胖大鼠模型,定期称量大鼠体重,实验末称量并统计其体脂,测定瘦素、MDA和GSH-Px水平。实验结果表明,低氧暴露和低氧暴露下耐力训练都能提高机体氧化应激水平,低氧运动对机体瘦素抵抗有良好的影响。大鼠血清瘦素水平与丙二醛、谷胱甘肽过氧化物酶水平显著相关,说明机体自由基代谢与瘦素及其敏感性相关。 To clarify the effects of different modes of hypoxic training on free radical metabolism in obese rats,and to explore the relationship between free radical metabolism and leptin sensitivity during hypoxic training.This study establishes an obese rat model,weighed the rats regularly,weighed and counted their body fat at the end of the experiment,and measured leptin,MDA and GSH-Px levels.The experimental results showed that both hypoxic exposure and endurance training under hypoxic exposure could increase the level of oxidative stress in the body,and hypoxic exercise had a good effect on leptin resistance in the body.The Serum leptin levels in rats were significantly correlated with malondialdehyde and glutathione peroxidase levels,suggesting that the body's free radical metabolism is related to leptin and its sensitivity.
作者 刘春阳 姚远 黄徐根 LIU Chunyang;YAO Yuan;HUANG Xugen(Physical Education Department,Anhui Wenda University of Information Engineering,Hefei 231201,China;School of Public Education,Jiangsu Agri-animal Husbandry College,Taizhou Anhui 225300,China;College of Physical Education,Anhui Normal University,Wuhu Anhui 241003,China)
出处 《佳木斯大学学报(自然科学版)》 CAS 2024年第2期154-156,180,共4页 Journal of Jiamusi University:Natural Science Edition
基金 安徽文达信息工程学院自然科学研究重点项目(XZR2021A19) 安徽高校省级自然科学研究重点项目(KJ2014A086)。
关键词 低氧训练 肥胖 瘦素 自由基 hypoxic training obesity leptin free radical
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