摘要
目的:探索分析中医药治疗脾胃湿热型慢性非萎缩性胃炎的用药规律。方法:收集中国知网数据库、万方数据库建库至2022年9月1日关于中医药治疗脾胃湿热证慢性非萎缩性胃炎的处方,筛选后导入中医传承计算平台V3.0,对录入处方中药物的使用频次、四气-五味、归经、功效进行分析,采用关联规则、k-means聚类算法进行演算进行分析。结果:共收集91首有效方剂,涉及中药112味。单味药用药频次以黄连最高,半夏次之;药性以寒性、温性为主,平性次之;药味以苦味、辛味最多,辅以甘味;归经中以脾经、胃经为主、肺经次之。功效主要为清热类药、补虚类药、化湿类药、理气类药。常用药物组合频次排前6位的分别为“黄连、半夏”“黄连、陈皮”“半夏、厚朴”“半夏、黄芩”“黄连、黄芩”“半夏、陈皮”;通过k-means聚类得到3对核心药物组合,分别为“黄连、半夏、陈皮、黄芩、厚朴”“厚朴、半夏、黄连、黄芩、甘草”“黄连、半夏、生姜、厚朴、苍术”。结论:中医药治疗脾胃湿热型慢性非萎缩性胃炎以清热燥湿、理气调中为治疗原则,以辛开苦降为重要指导思想,以恢复脾胃气机升降为主要目的,以半夏泻心汤及王氏连朴饮为治疗基础方。此方能通过降低机体炎症水平、抑制胃酸分泌、从而达到促进胃黏膜修复的作用,同时还能改善胃肠道动力,从而减轻患者临床症状,改善预后。
Objective:To explore and analyze the medication rule of treating chronic non-atrophic gastritis of the damp heat of spleen and stomach type in TCM based on data mining.Methods:In CNKI and Wanfang data,the prescriptions of TCM medicine for the treatment of chronic non-atrophic gastritis of the damp heat in the spleen and the stomach type from the establishment of the database to September 1,2022 were collected and screened and introduced into Traditional Chinese Medicine Inheritance Computing Platform V3.0.The frequency of use,four Qi(气)and five flavors,meridian properties,channels tropism and efficacy of the drugs in the prescription are analyzed.Association rules and k-means clustering algorithm are used for calculus analysis.Results:A total of 91 effective prescriptions were collected,involving 112 TCM medicines.The frequency of single medicine is the highest in Huanglian(Rhizoma Coptidis),followed by Banxia(Rhizoma Pinelliae).The main medicinal properties are cold and warm,followed by neutral.The bitter and pungent taste of the medicine is the heaviest,supplemented by sweet taste.The spleen channel and stomach channel are the main channels,followed by the lung channel.The main functions are heat-clearing drugs,deficiency-tonifying drugs,dampness-resolving drugs and Qi-regulating drugs.The top six commonly used drug combinations are Huanglian-Banxia,Huanglian-Chenpi(Pericarpium Citri Reticulatae),Banxia-Houpo(Cortex Magnoliae Officinali),Banxia-Huangqin(Radix Scutellariae),Huanglian-Huangqin,Banxia-Chenpi.Three pairs of core drug combinations were obtained by k-means clustering,which were Huanglian-Banxia-Chenpi-Huangqin-Houpo,Houpo-Banxia-Huanglian-Huangqin-Gancao(Radix Glycyrrhizae),Huanglian-Banxia-Shengjiang(Rhizoma Zingiberis Recens)-Houpo-Cangzhu(Rhizoma Atractylodis).Conclusion:TCM treatment of chronic non-atrophic gastritis of the damp heat of spleen and stomach type should be based on the principles of clearing heat,dispelling dampness,regulating Qi and middle-jiao(中焦).Take acrid-bitter herb as the important guiding ideology.The main purpose is to restore ascending or descending movement of vital Qi.Take the Banxia Xiexin decoction(半夏泻心汤)and WANG’s Lianpo Yin(王氏连朴饮)as the basic prescription for treatment.This prescription can not only reduce the level of inflammation,inhibit gastric acid secretion,promote the repair of gastric mucosa,but also improve gastrointestinal motility,reduce clinical symptoms and improve prognosis.
出处
《中医临床研究》
2024年第5期106-110,共5页
Clinical Journal Of Chinese Medicine
关键词
数据挖掘
脾胃湿热证
慢性非萎缩性胃炎
慢性浅表性胃炎
Data mining
The damp heat of spleen and stomach type
Chronic non-atrophic gastritis
Chronic superficial gastritis
