摘要
目的探讨连续性血液滤过联合床旁血流灌注在急性有机磷中毒患者急诊救治中的应用。方法回顾性分析我院急诊科2020年4月至2023年4月收治的106例急性有机磷中毒患者,依据不同急救方法将其分为对照组(n=56)和观察组(n=50)。对照组实施床旁血流灌注疗法,观察组在对照组基础上联合连续性血液滤过疗法。比较两组的急救效果。结果观察组的阿托品用量显著少于对照组,胆碱酯酶(ChE)恢复时间、住院时间显著短于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、谷丙转氨酶(ALT)、肌酸激酶(CK)及肌酸激酶同工酶MB(CK-MB)水平显著低于对照组(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论连续性血液滤过联合床旁血流灌注可加快急性有机磷中毒患者苏醒,调节炎性因子与血清指标水平。
Objective To explore the application of continuous hemofiltration combined with bedside hemoperfusion in emergency treatment of patients with acute organophosphorus poisoning.Methods A retrospective analysis of 106 patients with acute organophosphorus poisoning admitted in the emergency department of our hospital from April 2020 to April 2023 were divided into control group(n=56)and observation group(n=50)according to different first aid methods.The control group was given bedside hemoperfusion therapy,and the observation group was given continuous hemofiltration therapy on the basis of the control group.The first aid effects of the two groups were compared.Results The dosage of atropine in the observation group was significantly less than that in the control group,and the recovery time of cholinesterase(ChE)and hospitalization time were significantly shorter than those in the control group(P<0.05).After treatment,the levels of interlcukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),alanine aminotransferase(ALT),creatine kinase(CK)and creatine kinase isoenzyme MB(CK-MB)in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Continuous hemofiltration combined with bedside hemoperfusion can accelerate the recovery of patients with acute organophosphorus poisoning and regulate the levels of inflammatory factors and serum indicators.
作者
王秋平
WANG Qiuping(Emergency Department,Nanyang Central Hospital,Nanyang 473000,China)
出处
《临床医学研究与实践》
2024年第11期13-16,共4页
Clinical Research and Practice
基金
河南省医学科技攻关计划联合共建项目(No.LHGJ20200171)。
关键词
床旁血流灌注
连续性血液滤过
急性有机磷中毒
急诊救治
胆碱酯酶
bedside hemoperfusion
continuous hemofiltration
acute organophosphorus poisoning
emergency treatment
cholinesterase
