摘要
目的运用数据挖掘分析方法总结归纳补肾益髓类中药复方治疗阿尔茨海默病(alzheimer′s disease,AD)的核心药物及用药规律。方法将自数据库建立起至2022年4月于中文数据库中国知网、万方、维普,中国临床试验注册中心,英文数据库PubMed、Web of science中检索到的补肾益髓法治疗AD的临床研究文献作为数据来源,利用SPSS modeler 18.0和SPSS Statistic 25.0软件对纳入文献中记载的复方药物进行频次统计、关联分析、系统聚类分析和因子分析;通过Cytoscape 3.8.0构建中药核心复杂网络,并对网络中的中药进行拓扑分析。结果经筛选,得到69篇文献共计70首处方,108味中药;单味药物属熟地黄应用次数最高;补虚药、活血化瘀药、安神药应用最为广泛;网络拓扑学筛选得到包括熟地黄、石菖蒲、枸杞子、远志在内的12味核心中药;关联分析得到常用药物关联规则37条,最为常见的药对为“熟地黄-枸杞子”“石菖蒲-远志”等,使用频次最高的药物组合为“熟地黄-石菖蒲-远志”;系统聚类分析在欧式平方距离为15时可归纳为3个潜在聚类方,因子分析共提取4个公因子,其药物组成体现了地黄饮子、六味地黄丸、左归丸等补肾经方的药物配伍规律。结论补肾益髓法治疗AD以补肾填精益髓为主体,辅以活血祛瘀、宁心安神、豁痰开窍;针对AD病机治疗标本兼顾,体现了中医药整体观念、辨证施治的诊疗特点。
Objective To explore the medication characteristics and prescription rule of traditional Chinese Medicine(TCM)in the treatment of Alzheimer's Disease(AD)with the method of tonifying kidney and nourishing marrow by using data mining.Methods The tonify kidney and nourish marrow medical prescriptions in the treatment of AD from database estabilishment to April 2022 were searched from CNKI,Wanfang,Vip,ChiCTR,PubMed and Web of science database.Software SPSS Modeler 18.0 and SPSS Statistic 25.O were applied for frequency analysis,association rule analysis,cluster analysis and factor analysis in these prescriptions.A core complex network of TCM aim to topology analysis was built by using software Cytoscape 3.8.0.Results A total of 70 prescriptions were included,involving 108 single herbs.The most frequent used single herb is Rehmanniae Radix Praeparata.The efficacy of the drugs are mainly base on tonifying drugs,promoting blood and removing blood stasis drugs and sedative drugs.12 core herbs were screened out by topology analysis including Rehmanniae Radix Praeparata,Acori Tatarinowi Rhizoma,Lycii Fructus,Polygalae Radix and so on.37 medication association rules were found out and the most common medical combinations are Rehmanniae Radix Praeparata-Lycii Fructus,Acori Tatarinowii Rhizoma-Polygalae Radix,Rehmanniae Radix Praeparata-Acori Tatarinowi Rhizoma-Polygalae Radix.Cluster analysis shows when Euclidean square distance is 15,3 potential clustering prescriptions can be obtained and 4 common factors were extracted from factor analysis,which embodied the principle of medication in some classic prescriptions such as Rehmanniae decoction,Six-Ingredient Rehmannis Pill,Left-Restoring Pill.Conclusion The method of tonifying kidney and nourishing marrow in the treatment of AD is mainly composed of tonifying kidney and enriching the lean marrow,supplemented by promoting blood circulation,calming heart,tranquilizing mind and removing phlegm;directly treat on the pathogensis of AD from both external and internal,reflecting the characteristics of TCM treatment on concept of holism and syndrome differentiation.
作者
方德宇
张彬彬
张林
吴品昌
梁鸣展
FANG Deyu;ZHANG Binbin;ZHANG Lin;WU Pinchang;LIANG Mingzhan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;79th Army Hospital of the Chinese People's Liberation Army,Liaoyang 111000,Liaoning,China)
出处
《实用中医内科杂志》
2024年第3期14-18,I0004,I0005,共7页
Journal of Practical Traditional Chinese Internal Medicine
基金
国家自然科学基金项目(81803854)
辽宁省博士科研启动基金项目(2022-BS-206)
辽宁省教育厅科研项目(L202026)
大学生创新创业训练计划项目(S202010162012)
校级自然科学类重点项目(2021LZY048)。
关键词
阿尔茨海默病
补肾益髓
数据挖掘
核心中药
用药规律
Alzheimer's Disease
tonifying kidney and nourishing marrow
data mining
core herbs
medication rules
