摘要
目的:探讨甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)患者外周血CD19^(+)CD27^(+)IgD^(+)B细胞比例变化与病情活动度的关系。方法:采用流式细胞术检测TAO患者和健康对照组CD19^(+)CD27^(+)IgD^(+)B细胞比例,分析TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例与健康对照组的差异,并分析CD19^(+)CD27^(+)IgD^(+)B细胞比例与TAO疾病活动度之间的相关性。结果:TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例明显低于健康对照(P<0.05);活动性TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例细胞显著低于非活动性TAO患者;CD19^(+)CD27^(+)IgD^(+)B细胞比例与TAO患者CAS评分呈显著负相关(r=-0.7128,P<0.001)。结论:TAO患者CD19^(+)CD27^(+)IgD^(+)B细胞比例降低,与疾病活动度呈负相关。
Objective:To investigate the relationship between the proportion of CD19^(+)CD27^(+)IgD^(+)B cells in peripheral blood and disease activity in patients with thyroid-associated ophthalmopathy(TAO).Methods:Flow cytometry was used to detect the proportion of CD19^(+)CD27^(+)IgD^(+)B cells in TAO patients and healthy control groups.The difference in the proportion of CD19^(+)CD27^(+)IgD^(+)B cells between TAO patients and healthy control groups was analyzed.The correlation between the proportion of CD19^(+)CD27^(+)IgD^(+)B cells and activity was also analyzed.Results:The proportion of CD19^(+)CD27^(+)IgD^(+)B cells in TAO patients was significantly lower than that in healthy controls(P<0.05).The proportion of CD19^(+)CD27^(+)IgD^(+)B cells in active TAO patients was significantly lower than in inactive TAO patients.The proportion of CD19^(+)CD27^(+)IgD^(+)B cells was significantly negatively correlated with the CAS score of TAO patients(r=-0.7128,P<0.001).Conclusion:The proportion of CD19^(+)CD27^(+)IgD^(+)B cells in TAO patients is decreased,which is negatively correlated with disease activity.
作者
冯月兰
刘志英
王媛媛
张伟
FENG Yuelan;LIU Zhiying;WANG Yuanyuan;ZHANG Wei(First Affiliated Hospital of Baotou Medical College,Baotou 014010,China)
出处
《包头医学院学报》
CAS
2024年第4期33-37,共5页
Journal of Baotou Medical College
基金
内蒙古自治区自然科学基金项目(2021MS08047,2021MS08051,2023LHMS08018)
包头医学院科学研究基金项目(BYJJ-XG202004,BYJJ-QM 201926)
包头医学院青年科技计划项目(BYJJ-QNGG2022048)。
