摘要
基于磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路对中医药治疗慢传输型便秘的研究进行整理总结,以期为中医药治疗慢传输型便秘提供更多参考。通过整理分析发现,中药复方、中药单体、中药提取物、电针疗法可通过调控PI3K/Akt信号通路改善结肠传输动力和分泌,发挥通便的作用,主要机制涉及抗氧化应激、调节肠神经递质、调节细胞自噬、调节肠道水通道蛋白表达、修复受损肠神经元等途径,具有多成分、多靶点、多层次的优势。在未来仍需进一步研究,明确中医药的有效成分及其具体治疗靶点和机制,提高中医药治疗慢传输型便秘的临床疗效。
Based on the phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway,this study summarized the research on the treatment of slow transit constipation with traditional Chinese medicine(TCM)in order to provide more references for the treatment of slow transit constipation with TCM.Through sorting and analysis,it was found that TCM compound,TCM prescription,TCM extract and electroacupuncture therapy can improve colonic transmission power and secretion by regulating PI3K/Akt signaling pathway,and play a role in defecation.The main mechanism involved anti-oxidative stress,regulation of intestinal neurotransmitters,regulation of cell autophagy,regulation of intestinal aquaporin expression,repair of damaged intestinal neurons,and other pathways,with with advantages of multi-component,multi-target,and multi-level.In the future,further research was needed to clarify the effective ingredients of TCM and its specific therapeutic targets and mechanisms,so as to improve the clinical efficacy of TCM in the treatment of slow transit constipation.
作者
王红
吴容
张智彬
唐学贵
WANG Hong;WU Rong;ZHANG Zhibin;TANG Xuegui(Graduate School of North Sichuan Medical College,Nanchong Sichuang 637001,China;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuang 610075,China;Affiliated Hospital of North Sichuan Medical College,Nanchong Sichuang 637001,China)
出处
《中医药导报》
2024年第3期126-131,159,共7页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(82074429,81573990)。
