摘要
目的探究宫腔镜分别联合左炔诺孕酮宫内缓释系统与地屈孕酮片治疗排卵障碍性子宫出血(AUB-O)的临床疗效。方法选取本院80例AUB-O患者为研究对象,根据治疗方法的不同分为两组,各40例,均进行宫腔镜检查。A组术后给予地屈孕酮片治疗,B组术后给予左炔诺孕酮宫内缓释系统治疗,观察两组症状改善情况,比较两组治疗前后血红蛋白水平、月经量、子宫内膜厚度、视觉模拟评分法(VAS)评分、生活质量评分、临床疗效及不良反应发生情况。结果B组患者异常子宫出血症状缓解时间与消失时间均明显短于A组,差异有统计学意义(P<0.05)。治疗前,两组患者的血红蛋白水平、月经量、子宫内膜厚度、VAS评分及生活质量评分比较无统计学差异(P>0.05)。治疗1个月、3个月及6个月后,两组患者血红蛋白水平均明显升高,且B组高于A组;两组患者月经量、子宫内膜厚度和VAS评分明显降低,且B组低于A组,差异有统计学意义(P<0.05)。治疗后两组生活质量评分均明显升高,且B组高于A组,差异有统计学意义(P<0.05)。B组治疗总有效率为92.50%,高于A组的80.00%,差异有统计学意义(P<0.05)。B组不良反应总发生率为20.00%,低于A组的40.00%,差异有统计学意义(P<0.05)。结论宫腔镜联合左炔诺孕酮宫内缓释系统在改善AUB-O临床症状、提高临床疗效以及减轻不良反应方面比宫腔镜联合地屈孕酮片更有优势。
Objective To explore the clinical efficacy of hysteroscopy combined with levonorgestrel-releasing intrauterine system and dydrogesterone tablets in the treatment of ovulatory dysfunctional uterine bleeding(AUB-O).Methods 80 AUB-O patients in our hospital were selected as the research subjects,and were divided into two groups according to different treatment methods,40 cases each,both groups underwent hysteroscopy examination.Group A received postoperative treatment with dydrogesterone tablets,while Group B received postoperative treatment with levonorgestrel-releasing intrauterine system.The improvement of symptoms in both groups was observed,and hemoglobin levels,menstrual flow,endometrial thickness,VAS score,quality of life score,clinical efficacy,and incidence of adverse reactions were compared before and after treatment.Results The relief and disappearance time of abnormal uterine bleeding symptoms in Group B patients were significantly shorter than those in Group A,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in hemoglobin levels,menstrual flow,endometrial thickness,VAS scores,and quality of life scores between the two groups of patients(P>0.05).After 1 month,3 months,and 6 months of treatment,the hemoglobin levels of both groups of patients significantly increased,and Group B was higher than Group A.The menstrual flow,endometrial thickness,and VAS score of the two groups of patients were significantly reduced,and Group B was lower than Group A,with statistical significance(P<0.05).After treatment,the quality of life scores of both groups significantly increased,and Group B was higher than Group A,with a statistically significant difference(P<0.05).The effective rate of treatment in Group B was 92.50%,which was higher than Group A's 80.00%,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in Group B was 20.00%,lower than Group A's 40.00%,and the difference was statistically significant(P<0.05).Conclusion Hysteroscopy combined with levonorgestrel-releasing intrauterine system has more advantages in improving clinical symptoms,enhancing clinical efficacy,and reducing adverse reactions in AUB-O compared to hysteroscopy combined with dexmedetone tablets.
作者
库乐曼·巴依别克
李新
王娟
木克热木·苏里堂
Kuleman·Bayibieke;Li Xin;Wang Juan;Mukeremu·Sulitang(Department of Gynaecology,Xinhua Hospital of Yili Prefecture,Yining 835000,China)
出处
《实用妇科内分泌电子杂志》
2024年第3期64-67,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
排卵障碍性子宫出血
宫腔镜
左炔诺孕酮宫内缓释系统
地屈孕酮片
Ovulation disorders
Abnormal uterine bleeding
Hysteroscopy
Levonorgestrel-releasing intrauterine system
Dydrogesterone tablets
